biostudies-literatureUnknown13(9)Jiang CSpontaneous type 2 diabetes mellitus (T2DM) macaques are valuable resources for our understanding the pathological mechanism of T2DM. Based on one month's fasting blood glucose survey, we identified seven spontaneous T2DM macaques and five impaired glucose regulation (IGR) macaques from 1408 captive individuals. FPG, HbA1c, FPI and IR values were significant higher in T2DM and IGR than in controls. 16S rRNA sequencing of fecal microbes showed the significantly greater abundance of <i>Oribacterium</i>, bacteria inhibiting the production of secondary bile acids, and <i>Phascolarctobacterium</i>, bacteria producing short-chain fatty acids was significantly lower in T2DM macaques. In addition, several opportunistic pathogens, such as <i>Mogibacterium</i> and <i>Kocuria</i> were significantly mGenes1513https://www.ebi.ac.uk/biostudies/studies/S-EPMC9498908biostudies-literatureAlterations in Microbiota and Metabolites Related to Spontaneous Diabetes and Pre-Diabetes in Rhesus Macaques.PMC9498908Pan XLiu XLiu YLi JLuo JHu GLei GJiang CZhang LfalseAlterations in Microbiota and Metabolites Related to Spontaneous Diabetes and Pre-Diabetes in Rhesus Macaques.Spontaneous type 2 diabetes mellitus (T2DM) macaques are valuable resources for our understanding the pathological mechanism of T2DM. Based on one month's fasting blood glucose survey, we identified seven spontaneous T2DM macaques and five impaired glucose regulation (IGR) macaques from 1408 captive individuals. FPG, HbA1c, FPI and IR values were significant higher in T2DM and IGR than in controls. 16S rRNA sequencing of fecal microbes showed the significantly greater abundance of <i>Oribacterium</i>, bacteria inhibiting the production of secondary bile acids, and <i>Phascolarctobacterium</i>, bacteria producing short-chain fatty acids was significantly lower in T2DM macaques. In addition, several opportunistic pathogens, such as <i>Mogibacterium</i> and <i>Kocuria</i> were significantly m2022-01-01T00:00:00Z2022 Aug2025-04-21T14:19:31.901Z2024-11-07T00:50:42.341ZS-EPMC94989083614068310.3390/genes13091513