{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(9)"],"submitter":["den Braanker D"],"pubmed_abstract":["Recurrence of proteinuria after kidney transplantation in primary focal segmental glomerulosclerosis (FSGS) is unpredictable. Several putative circulating permeability factors (CPFs) have been suggested, but none have been validated. A clinically relevant experimental model is required that demonstrates the presence of CPF(s) in patient material, to study CPF(s) and possibly predict recurrence in patients. We aimed to develop a FSGS-prone Thy-1.1 transgenic mouse model with accelerated proteinuria after injection of samples from patients with FSGS. The Thy-1.1 transgene was backcrossed into 5 mouse strains. The age of onset and severity of spontaneous proteinuria varied between the different genetic backgrounds. 129X1/SvThy-1.1 and 129S2/SvPasThy-1.1 mice displayed proteinuria at 4 weeks, "],"journal":["PloS one"],"pagination":["e0274959"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9499224"],"repository":["biostudies-literature"],"pubmed_title":["Novel mouse strains to study circulating permeability factor(s) in primary focal segmental glomerulosclerosis."],"pmcid":["PMC9499224"],"pubmed_authors":["Maas R","Nijenhuis T","van der Vlag J","Smeets B","den Braanker D","Deegens J","Wetzels J","Parr N"],"additional_accession":[]},"is_claimable":false,"name":"Novel mouse strains to study circulating permeability factor(s) in primary focal segmental glomerulosclerosis.","description":"Recurrence of proteinuria after kidney transplantation in primary focal segmental glomerulosclerosis (FSGS) is unpredictable. Several putative circulating permeability factors (CPFs) have been suggested, but none have been validated. A clinically relevant experimental model is required that demonstrates the presence of CPF(s) in patient material, to study CPF(s) and possibly predict recurrence in patients. We aimed to develop a FSGS-prone Thy-1.1 transgenic mouse model with accelerated proteinuria after injection of samples from patients with FSGS. The Thy-1.1 transgene was backcrossed into 5 mouse strains. The age of onset and severity of spontaneous proteinuria varied between the different genetic backgrounds. 129X1/SvThy-1.1 and 129S2/SvPasThy-1.1 mice displayed proteinuria at 4 weeks, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T20:53:06.658Z","creation":"2025-04-07T08:58:07.769Z"},"accession":"S-EPMC9499224","cross_references":{"pubmed":["36137166"],"doi":["10.1371/journal.pone.0274959"]}}