{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang H"],"funding":["Shaanxi Science Fund for Distinguished Young Scholars","National Natural Science Foundation of China"],"pagination":["10445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9499528"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["Fusarium head blight (FHB), caused by the fungal pathogen <i>Fusarium graminearum</i>, is a destructive disease worldwide. Ascospores are the primary inoculum of <i>F. graminearum</i>, and sexual reproduction is a critical step in its infection cycle. In this study, we characterized the functions of FgCsn12. Although the ortholog of FgCsn12 in budding yeast was reported to have a direct interaction with Csn5, which served as the core subunit of the COP9 signalosome, the interaction between FgCsn12 and FgCsn5 was not detected through the yeast two-hybrid assay. The deletion of <i>FgCSN12</i> resulted in slight defects in the growth rate, conidial morphology, and pathogenicity. Instead of forming four-celled, uninucleate ascospores, the <i>Fgcsn12</i> deletion mutant produced oval ascospores"],"journal":["International journal of molecular sciences"],"pubmed_title":["FgCsn12 Is Involved in the Regulation of Ascosporogenesis in the Wheat Scab Fungus <i>Fusarium graminearum</i>."],"pmcid":["PMC9499528"],"funding_grant_id":["2022JC-14","32102181"],"pubmed_authors":["Liu H","Cao X","Qi J","Zhang Y","Wang C","Jiang H","Wang W","Jiang C","Xu H"],"additional_accession":[]},"is_claimable":false,"name":"FgCsn12 Is Involved in the Regulation of Ascosporogenesis in the Wheat Scab Fungus <i>Fusarium graminearum</i>.","description":"Fusarium head blight (FHB), caused by the fungal pathogen <i>Fusarium graminearum</i>, is a destructive disease worldwide. Ascospores are the primary inoculum of <i>F. graminearum</i>, and sexual reproduction is a critical step in its infection cycle. In this study, we characterized the functions of FgCsn12. Although the ortholog of FgCsn12 in budding yeast was reported to have a direct interaction with Csn5, which served as the core subunit of the COP9 signalosome, the interaction between FgCsn12 and FgCsn5 was not detected through the yeast two-hybrid assay. The deletion of <i>FgCSN12</i> resulted in slight defects in the growth rate, conidial morphology, and pathogenicity. Instead of forming four-celled, uninucleate ascospores, the <i>Fgcsn12</i> deletion mutant produced oval ascospores","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-21T16:10:00.472Z","creation":"2025-02-19T00:42:06.432Z"},"accession":"S-EPMC9499528","cross_references":{"pubmed":["36142356"],"doi":["10.3390/ijms231810445"]}}