{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang X"],"funding":["NINDS NIH HHS"],"pagination":["e2204229119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9499536"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(38)"],"pubmed_abstract":["Forgetting is an essential component of the brain's memory management system, providing a balance to memory formation processes by removing unused or unwanted memories, or by suppressing their expression. However, the molecular, cellular, and circuit mechanisms underlying forgetting are poorly understood. Here we show that the memory suppressor gene, <i>sickie</i>, functions in a single dopamine neuron (DAn) by supporting the process of active forgetting in <i>Drosophila</i>. RNAi knockdown (KD) of <i>sickie</i> impairs forgetting by reducing the Ca<sup>2+</sup> influx and DA release from the DAn that promotes forgetting. Coimmunoprecipitation/mass spectrometry analyses identified cytoskeletal and presynaptic active zone (AZ) proteins as candidates that physically interact with Sickie, and"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Active forgetting requires Sickie function in a dedicated dopamine circuit in <i>Drosophila</i>."],"pmcid":["PMC9499536"],"funding_grant_id":["R37 NS019904","R35 NS097224"],"pubmed_authors":["Davis RL","Zhang X","Tsaprailis G","Sabandal JM"],"additional_accession":[]},"is_claimable":false,"name":"Active forgetting requires Sickie function in a dedicated dopamine circuit in <i>Drosophila</i>.","description":"Forgetting is an essential component of the brain's memory management system, providing a balance to memory formation processes by removing unused or unwanted memories, or by suppressing their expression. However, the molecular, cellular, and circuit mechanisms underlying forgetting are poorly understood. Here we show that the memory suppressor gene, <i>sickie</i>, functions in a single dopamine neuron (DAn) by supporting the process of active forgetting in <i>Drosophila</i>. RNAi knockdown (KD) of <i>sickie</i> impairs forgetting by reducing the Ca<sup>2+</sup> influx and DA release from the DAn that promotes forgetting. Coimmunoprecipitation/mass spectrometry analyses identified cytoskeletal and presynaptic active zone (AZ) proteins as candidates that physically interact with Sickie, and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:52:23.318Z","creation":"2025-04-05T21:55:38.891Z"},"accession":"S-EPMC9499536","cross_references":{"pubmed":["36095217"],"doi":["10.1073/pnas.2204229119"]}}