{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dai Z"],"funding":["President Foundation of The Third Affiliated Hospital of Southern Medical University","Guangdong Basic and Applied Basic Research Foundation","National Natural Science Foundation of China","China Postdoctoral Science Foundation"],"pagination":["1392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9501550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["The slow proliferation rate and poor osteodifferentiation ability of inflammatory periodontal membrane stem cells extracted from periodontitis tissues (i-PDLSCs) account for poor efficiency in treating inflammatory bone loss. Exosomes reportedly have inducible and relatively stable components, allowing them to promote inflammatory bone repair, but obtaining i-PDLSCs exosomes with the ability to promote osteodifferentiation is challenging. In the present study, i-PDLSCs were extracted from periodontal membrane tissues of patients with severe periodontitis, and in vitro induction with gallic acid (GA) significantly promoted the proliferative activity of i-PDLSCs at a concentration of 10 mM, with TC<sub>0</sub> of 11.057 mM and TC<sub>50</sub> of 67.56 mM for i-PDLSCs. After mRNA sequencing, "],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["Gallic Acid Ameliorates the Inflammatory State of Periodontal Ligament Stem Cells and Promotes Pro-Osteodifferentiation Capabilities of Inflammatory Stem Cell-Derived Exosomes."],"pmcid":["PMC9501550"],"funding_grant_id":["2021M701620","2021A1515111074","31972915","82073747","YQ2021001"],"pubmed_authors":["Yang J","Li Z","Yan Z","Li S","Xiao J","Huang W","Zhang L","Zheng W","Sun H","Dai Z"],"additional_accession":[]},"is_claimable":false,"name":"Gallic Acid Ameliorates the Inflammatory State of Periodontal Ligament Stem Cells and Promotes Pro-Osteodifferentiation Capabilities of Inflammatory Stem Cell-Derived Exosomes.","description":"The slow proliferation rate and poor osteodifferentiation ability of inflammatory periodontal membrane stem cells extracted from periodontitis tissues (i-PDLSCs) account for poor efficiency in treating inflammatory bone loss. Exosomes reportedly have inducible and relatively stable components, allowing them to promote inflammatory bone repair, but obtaining i-PDLSCs exosomes with the ability to promote osteodifferentiation is challenging. In the present study, i-PDLSCs were extracted from periodontal membrane tissues of patients with severe periodontitis, and in vitro induction with gallic acid (GA) significantly promoted the proliferative activity of i-PDLSCs at a concentration of 10 mM, with TC<sub>0</sub> of 11.057 mM and TC<sub>50</sub> of 67.56 mM for i-PDLSCs. After mRNA sequencing, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T02:17:51.887Z","creation":"2024-10-19T08:20:17.426Z"},"accession":"S-EPMC9501550","cross_references":{"pubmed":["36143428"],"doi":["10.3390/life12091392"]}}