biostudies-literatureMikhalchik ERussian Science FoundationDevelopment Program of Lomonosov MSU and registration theme10579https://www.ebi.ac.uk/biostudies/studies/S-EPMC9501559biostudies-literatureUnknown23(18)Nano- and microparticles enter the body through the respiratory airways and the digestive system, or form as biominerals in the gall bladder, salivary glands, urinary bladder, kidney, or diabetic pancreas. Calcium, magnesium, and phosphate ions can precipitate from biological fluids in the presence of mucin as hybrid nanoparticles. Calcium carbonate nanocrystallites also trap mucin and are assembled into hybrid microparticles. Both mucin and calcium carbonate polymorphs (calcite, aragonite, and vaterite) are known to be components of such biominerals as gallstones which provoke inflammatory reactions. Our study was aimed at evaluation of neutrophil activation by hybrid vaterite-mucin microparticles (CCM). Vaterite microparticles (CC) and CCM were prepared under standard conditions. The diaInternational journal of molecular sciencesActivation of Neutrophils by Mucin-Vaterite Microparticles.PMC9501559121041500039-820-1500390Pronkin EAMorozova OVKlinov DVBespyatykh JABasyreva LYBarinov NAFilatova LYPanasenko OMBalabushevich NGGusev SAMoscalets APMikhalchik EMaltseva LNfalseActivation of Neutrophils by Mucin-Vaterite Microparticles.Nano- and microparticles enter the body through the respiratory airways and the digestive system, or form as biominerals in the gall bladder, salivary glands, urinary bladder, kidney, or diabetic pancreas. Calcium, magnesium, and phosphate ions can precipitate from biological fluids in the presence of mucin as hybrid nanoparticles. Calcium carbonate nanocrystallites also trap mucin and are assembled into hybrid microparticles. Both mucin and calcium carbonate polymorphs (calcite, aragonite, and vaterite) are known to be components of such biominerals as gallstones which provoke inflammatory reactions. Our study was aimed at evaluation of neutrophil activation by hybrid vaterite-mucin microparticles (CCM). Vaterite microparticles (CC) and CCM were prepared under standard conditions. The dia2022-01-01T00:00:00Z2022 Sep2025-04-18T21:51:20.494Z2025-04-07T09:42:08.501ZS-EPMC95015593614249210.3390/ijms231810579