biostudies-literatureZou ZYShenzhen Second People’s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction ProjectShenzhen Science and Technology Innovation CommissionSanming Project of Medicine in Shenzhentkac029https://www.ebi.ac.uk/biostudies/studies/S-EPMC9501718biostudies-literatureUnknown10<h4>Background</h4>Minimal data exist on anticoagulation use and timing and the dose of heparin in patients with sepsis, and whether heparin use improves sepsis survival remains largely unclear. This study was performed to assess whether heparin administration would provide a survival advantage in critically ill patients with sepsis.<h4>Methods</h4>A retrospective cohort study of patients with sepsis in the Medical Information Mart for Intensive Care (MIMIC)-IV database was conducted. Cox proportional hazards model and propensity score matching (PSM) were used to evaluate the outcomes of prophylactic anticoagulation with heparin administered by subcutaneous injection within 48 h of intensive care unit (ICU) admission. The primary outcome was in-hospital mortality. Secondary outcomes includBurns & traumaEarly prophylactic anticoagulation with heparin alleviates mortality in critically ill patients with sepsis: a retrospective analysis from the MIMIC-IV database.PMC950171820173357201815JCYJ2019080616360350420203357014SZSM2016201120193357003Luan YYYang ZJZhang JJHuang JJWu MYao YMZhou ZPZou ZYfalseEarly prophylactic anticoagulation with heparin alleviates mortality in critically ill patients with sepsis: a retrospective analysis from the MIMIC-IV database.<h4>Background</h4>Minimal data exist on anticoagulation use and timing and the dose of heparin in patients with sepsis, and whether heparin use improves sepsis survival remains largely unclear. This study was performed to assess whether heparin administration would provide a survival advantage in critically ill patients with sepsis.<h4>Methods</h4>A retrospective cohort study of patients with sepsis in the Medical Information Mart for Intensive Care (MIMIC)-IV database was conducted. Cox proportional hazards model and propensity score matching (PSM) were used to evaluate the outcomes of prophylactic anticoagulation with heparin administered by subcutaneous injection within 48 h of intensive care unit (ICU) admission. The primary outcome was in-hospital mortality. Secondary outcomes includ2022-01-01T00:00:00Z20222026-04-08T11:39:38.854Z2025-04-19T22:46:46.044ZS-EPMC95017183616840210.1093/burnst/tkac029