{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abu Bakar N"],"funding":["Universiti Putra Malaysia","Ministry of Higher Education, Malaysia, under the Transdisciplinary-Fundamental Research Grant Scheme (TRGS)","Universiti Putra Malaysia under the Putra Grant Scheme","Ministry of Higher Education","Korean Ministry of Environment (MOE)","Fundamental Research Grant Scheme (FRGS)","Ministry of Environment"],"pagination":["493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502072"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(9)"],"pubmed_abstract":["Arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) is a ubiquitous heavy metal in the environment. Exposure to this toxin at low concentrations is unremarkable in developing organisms. Nevertheless, understanding the underlying mechanism of its long-term adverse effects remains a challenge. In this study, embryos were initially exposed to As<sub>2</sub>O<sub>3</sub> from gastrulation to hatching under semi-static conditions. Results showed dose-dependent increased mortality, with exposure to 30-40 µM As<sub>2</sub>O<sub>3</sub> significantly reducing tail-coiling and heart rate at early larval stages. Surviving larvae after 30 µM As<sub>2</sub>O<sub>3</sub> exposure showed deficits in motor behavior without impairment of anxiety-like responses at 6 dpf and a slight impairment in color preference behavior at 11 dpf, which was later evident in adulthood. As<sub>2</sub>O<sub>3</sub> also altered locomotor function, with a loss of directional and color preference in adult zebrafish, which correlated with changes in transcriptional regulation of <i>adsl</i>, <i>shank3a</i>, and <i>tsc1b</i> genes. During these processes, As<sub>2</sub>O<sub>3</sub> mainly induced metabolic changes in lipids, particularly arachidonic acid, docosahexaenoic acid, prostaglandin, and sphinganine-1-phosphate in the post-hatching period of zebrafish. Overall, this study provides new insight into the potential mechanism of arsenic toxicity leading to long-term learning impairment in zebrafish and may benefit future risk assessments of other environmental toxins of concern."],"journal":["Toxics"],"pubmed_title":["Embryonic Arsenic Exposure Triggers Long-Term Behavioral Impairment with Metabolite Alterations in Zebrafish."],"pmcid":["PMC9502072"],"funding_grant_id":["UPM/700-2/1/GP/2017/9550900","FRGS/1/2018/STG03/UPM/02/2","RE2021003310003","TD-FRGS/2/2013/UPM/02/1/3"],"pubmed_authors":["Abu Bakar N","Mediani A","Kim CH","Ramlan NF","Che Abdullah CA","Wan Ibrahim WN","Nasruddin NS","Shaari K","Shohaimi S","Mohd Faudzi SM"],"additional_accession":[]},"is_claimable":false,"name":"Embryonic Arsenic Exposure Triggers Long-Term Behavioral Impairment with Metabolite Alterations in Zebrafish.","description":"Arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) is a ubiquitous heavy metal in the environment. Exposure to this toxin at low concentrations is unremarkable in developing organisms. Nevertheless, understanding the underlying mechanism of its long-term adverse effects remains a challenge. In this study, embryos were initially exposed to As<sub>2</sub>O<sub>3</sub> from gastrulation to hatching under semi-static conditions. Results showed dose-dependent increased mortality, with exposure to 30-40 µM As<sub>2</sub>O<sub>3</sub> significantly reducing tail-coiling and heart rate at early larval stages. Surviving larvae after 30 µM As<sub>2</sub>O<sub>3</sub> exposure showed deficits in motor behavior without impairment of anxiety-like responses at 6 dpf and a slight impairment in color preference behavior at 11 dpf, which was later evident in adulthood. As<sub>2</sub>O<sub>3</sub> also altered locomotor function, with a loss of directional and color preference in adult zebrafish, which correlated with changes in transcriptional regulation of <i>adsl</i>, <i>shank3a</i>, and <i>tsc1b</i> genes. During these processes, As<sub>2</sub>O<sub>3</sub> mainly induced metabolic changes in lipids, particularly arachidonic acid, docosahexaenoic acid, prostaglandin, and sphinganine-1-phosphate in the post-hatching period of zebrafish. Overall, this study provides new insight into the potential mechanism of arsenic toxicity leading to long-term learning impairment in zebrafish and may benefit future risk assessments of other environmental toxins of concern.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-20T03:24:29.134Z","creation":"2025-04-07T08:59:09.704Z"},"accession":"S-EPMC9502072","cross_references":{"pubmed":["36136458"],"doi":["10.3390/toxics10090493"]}}