{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai B"],"funding":["Natural Science Key Research Program of Anhui Province University"],"pagination":["10954"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502174"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["Seven undescribed phenylpropanoid constituents, including three new bibenzyl derivatives (<b>1</b>-<b>3</b>) along with four new benzofuran stilbene derivatives (<b>4</b>-<b>7</b>), were isolated from the aerial parts of <i>Dioscorea polystachya</i>. The structures of these compounds were elucidated using a combination of spectroscopic analyses, including UV, IR, HRESIMS, 1D, and 2D NMR. Further, all the compounds were evaluated on the anti-inflammatory activity for their inhibition of nitric oxide (NO) production by RAW 264.7 macrophages cells, and some of them (<b>1</b>-<b>3</b> and <b>6</b>) displayed inhibitory activity with IC<sub>50</sub> values in the range of 9.3-32.3 μM. Moreover, compound <b>3</b> decreased the expression of iNOS in Western blot analysis, suggesting compound <b>3</b> is mediated via the suppression of an LPS-induced NF-κB inflammasome pathway."],"journal":["International journal of molecular sciences"],"pubmed_title":["Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts of <i>Dioscorea polystachya</i>."],"pmcid":["PMC9502174"],"funding_grant_id":["KJ2020A0915"],"pubmed_authors":["Cai B","Xu T","Wang J","Cai X","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Structures and Anti-Inflammatory Evaluation of Phenylpropanoid Derivatives from the Aerial Parts of <i>Dioscorea polystachya</i>.","description":"Seven undescribed phenylpropanoid constituents, including three new bibenzyl derivatives (<b>1</b>-<b>3</b>) along with four new benzofuran stilbene derivatives (<b>4</b>-<b>7</b>), were isolated from the aerial parts of <i>Dioscorea polystachya</i>. The structures of these compounds were elucidated using a combination of spectroscopic analyses, including UV, IR, HRESIMS, 1D, and 2D NMR. Further, all the compounds were evaluated on the anti-inflammatory activity for their inhibition of nitric oxide (NO) production by RAW 264.7 macrophages cells, and some of them (<b>1</b>-<b>3</b> and <b>6</b>) displayed inhibitory activity with IC<sub>50</sub> values in the range of 9.3-32.3 μM. Moreover, compound <b>3</b> decreased the expression of iNOS in Western blot analysis, suggesting compound <b>3</b> is mediated via the suppression of an LPS-induced NF-κB inflammasome pathway.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-21T14:27:29.675Z","creation":"2025-04-21T14:27:29.675Z"},"accession":"S-EPMC9502174","cross_references":{"pubmed":["36142867"],"doi":["10.3390/ijms231810954"]}}