{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iwama R"],"funding":["Institute for Fermentation"],"pagination":["975"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502257"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(9)"],"pubmed_abstract":["SMTP (the name SMTP is derived from <i>Stachybotrys microspora</i> triprenyl phenol) is a family of triprenyl phenol secondary metabolites from a black mold, <i>Stachybotrys microspora</i>. Some SMTP congeners exhibit anti-inflammatory and profibrinolytic activities that, in combination, contribute to the treatment of ischemic stroke. The final step in the SMTP biosynthesis is a non-enzymatic amine conjugation with an <i>o</i>-phthalaldehyde moiety of the precursor pre-SMTP, which can form adducts with proteins and nucleic acids. Thus, pre-SMTP formation should be a precisely regulated, rate-limiting step in the SMTP biosynthesis. To address the mechanism backing this regulation, we purified a metabolite that rapidly disappeared following amine feeding, identifying a novel compound, pri-SM"],"journal":["Journal of fungi (Basel, Switzerland)"],"pubmed_title":["Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in <i>Stachybotrys</i>: Possible Implication in Nitrogen Acquisition."],"pmcid":["PMC9502257"],"funding_grant_id":["G-25-2-10"],"pubmed_authors":["Hasumi K","Sasano Y","Hiramatsu T","Iwama R","Suzuki E","Otake S"],"additional_accession":[]},"is_claimable":false,"name":"Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in <i>Stachybotrys</i>: Possible Implication in Nitrogen Acquisition.","description":"SMTP (the name SMTP is derived from <i>Stachybotrys microspora</i> triprenyl phenol) is a family of triprenyl phenol secondary metabolites from a black mold, <i>Stachybotrys microspora</i>. Some SMTP congeners exhibit anti-inflammatory and profibrinolytic activities that, in combination, contribute to the treatment of ischemic stroke. The final step in the SMTP biosynthesis is a non-enzymatic amine conjugation with an <i>o</i>-phthalaldehyde moiety of the precursor pre-SMTP, which can form adducts with proteins and nucleic acids. Thus, pre-SMTP formation should be a precisely regulated, rate-limiting step in the SMTP biosynthesis. To address the mechanism backing this regulation, we purified a metabolite that rapidly disappeared following amine feeding, identifying a novel compound, pri-SM","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-06-01T00:11:22.957Z","creation":"2025-02-19T00:41:50.139Z"},"accession":"S-EPMC9502257","cross_references":{"pubmed":["36135700"],"doi":["10.3390/jof8090975"]}}