{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen C"],"funding":["Guangdong Marine Economy Development Special Project","National Natural Science Foundation of China"],"pagination":["583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(9)"],"pubmed_abstract":["Four new polyketide compounds, including two new unique isocoumarins penicillol A (<b>1</b>) and penicillol B (<b>2</b>) featuring with spiroketal rings, two new citreoviridin derivatives citreoviridin H (<b>3</b>) and citreoviridin I (<b>4</b>), along with four known analogues were isolated from the mangrove endophytic fungus <i>Penicillium</i> sp. BJR-P2. Their structures were elucidated by extensive spectroscopic methods. The absolute configurations of compounds <b>1</b>-<b>4</b> based on electronic circular dichroism (ECD) calculations, DP4+ analysis, and single-crystal X-ray diffraction are presented. All the new compounds were evaluated for anti-inflammatory activity. An anti-inflammatory assay indicated that compound <b>2</b> inhibited lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 12 μM, being more potent than the positive control, indomethacin (IC<sub>50</sub> = 35.8 ± 5.7 μM). Docking study showed that compound <b>2</b> was perfectly docking into the active site of murine inducible nitric oxide oxygenase (iNOS) via forming multiple typical hydrogen bonds."],"journal":["Marine drugs"],"pubmed_title":["New Polyketides from Mangrove Endophytic Fungus <i>Penicillium</i> sp. BJR-P2 and Their Anti-Inflammatory Activity."],"pmcid":["PMC9502265"],"funding_grant_id":["No. 41876153","41876153","No. GDNRC [2022]35"],"pubmed_authors":["Tang J","Li J","Wu L","Long Y","Ye G","Chen C","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"New Polyketides from Mangrove Endophytic Fungus <i>Penicillium</i> sp. BJR-P2 and Their Anti-Inflammatory Activity.","description":"Four new polyketide compounds, including two new unique isocoumarins penicillol A (<b>1</b>) and penicillol B (<b>2</b>) featuring with spiroketal rings, two new citreoviridin derivatives citreoviridin H (<b>3</b>) and citreoviridin I (<b>4</b>), along with four known analogues were isolated from the mangrove endophytic fungus <i>Penicillium</i> sp. BJR-P2. Their structures were elucidated by extensive spectroscopic methods. The absolute configurations of compounds <b>1</b>-<b>4</b> based on electronic circular dichroism (ECD) calculations, DP4+ analysis, and single-crystal X-ray diffraction are presented. All the new compounds were evaluated for anti-inflammatory activity. An anti-inflammatory assay indicated that compound <b>2</b> inhibited lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 12 μM, being more potent than the positive control, indomethacin (IC<sub>50</sub> = 35.8 ± 5.7 μM). Docking study showed that compound <b>2</b> was perfectly docking into the active site of murine inducible nitric oxide oxygenase (iNOS) via forming multiple typical hydrogen bonds.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T11:48:46.336Z","creation":"2025-02-19T00:44:27.407Z"},"accession":"S-EPMC9502265","cross_references":{"pubmed":["36135772"],"doi":["10.3390/md20090583"]}}