{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(18)"],"submitter":["Boravleva E"],"pubmed_abstract":["Avian influenza viruses (AIV) of wild ducks are known to be able to sporadically infect domestic birds and spread along poultry. Regular surveillance of AIV in the wild is needed to prepare for potential outbreaks. During long-year monitoring, 46 strains of AIV were isolated from gulls and mallards in Moscow ponds and completely sequenced. Amino acid positions that affect the pathogenicity of influenza viruses in different hosts were tested. The binding affinity of the virus for receptors analogs typical for different hosts and the pathogenicity of viruses for mice and chickens were investigated. Moscow isolates did not contain well-known markers of pathogenicity and/or adaptation to mammals, so as a polybasic cleavage site in HA, substitutions of 226Q and 228G amino acids in the receptor-"],"journal":["International journal of molecular sciences"],"pagination":["10829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502348"],"repository":["biostudies-literature"],"pubmed_title":["Molecular Characteristics, Receptor Specificity, and Pathogenicity of Avian Influenza Viruses Isolated from Wild Ducks in Russia."],"pmcid":["PMC9502348"],"pubmed_authors":["Prilipov A","Lomakina N","Belyakova A","Gambaryan A","Postnikova Y","Sadykova G","Boravleva E","Ishmukhametov A","Treshchalina A"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Characteristics, Receptor Specificity, and Pathogenicity of Avian Influenza Viruses Isolated from Wild Ducks in Russia.","description":"Avian influenza viruses (AIV) of wild ducks are known to be able to sporadically infect domestic birds and spread along poultry. Regular surveillance of AIV in the wild is needed to prepare for potential outbreaks. During long-year monitoring, 46 strains of AIV were isolated from gulls and mallards in Moscow ponds and completely sequenced. Amino acid positions that affect the pathogenicity of influenza viruses in different hosts were tested. The binding affinity of the virus for receptors analogs typical for different hosts and the pathogenicity of viruses for mice and chickens were investigated. Moscow isolates did not contain well-known markers of pathogenicity and/or adaptation to mammals, so as a polybasic cleavage site in HA, substitutions of 226Q and 228G amino acids in the receptor-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T07:29:03.891Z","creation":"2025-04-19T07:29:03.891Z"},"accession":"S-EPMC9502348","cross_references":{"pubmed":["36142740"],"doi":["10.3390/ijms231810829"]}}