{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lusardi M"],"funding":["Ministero della Salute","University of Genoa"],"pagination":["5814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502416"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(18)"],"pubmed_abstract":["A small library of highly functionalized phenylaminopyrazoles, bearing different substituents at position 1, 3, and 4 of the pyrazole ring, was prepared by the one-pot condensation of active methylene reagents, phenylisothiocyanate, and substituted hydrazine (namely, methyl- and benzyl-hydrazine). The identified reaction conditions proved to be versatile and efficient. Furthermore, the evaluation of alternative stepwise protocols affected the chemo- and regio-selectivity outcome of the one-pot procedure. The chemical identities of two <i>N</i>-methyl pyrazole isomers, selected as prototypes of the whole series, were unambiguously identified by means of NMR and mass spectrometry studies. Additionally, semiempirical calculations provided a structural rationale for the different chromatograph"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Regioselective Synthesis, Structural Characterization, and Antiproliferative Activity of Novel Tetra-Substituted Phenylaminopyrazole Derivatives."],"pmcid":["PMC9502416"],"funding_grant_id":["Fondo di Ricerca d'Ateneo (FRA)","Ricerca corrente 2021"],"pubmed_authors":["Profumo A","Rosano C","Iervasi E","Ponassi M","Spallarossa A","Rotolo C","Lusardi M"],"additional_accession":[]},"is_claimable":false,"name":"Regioselective Synthesis, Structural Characterization, and Antiproliferative Activity of Novel Tetra-Substituted Phenylaminopyrazole Derivatives.","description":"A small library of highly functionalized phenylaminopyrazoles, bearing different substituents at position 1, 3, and 4 of the pyrazole ring, was prepared by the one-pot condensation of active methylene reagents, phenylisothiocyanate, and substituted hydrazine (namely, methyl- and benzyl-hydrazine). The identified reaction conditions proved to be versatile and efficient. Furthermore, the evaluation of alternative stepwise protocols affected the chemo- and regio-selectivity outcome of the one-pot procedure. The chemical identities of two <i>N</i>-methyl pyrazole isomers, selected as prototypes of the whole series, were unambiguously identified by means of NMR and mass spectrometry studies. Additionally, semiempirical calculations provided a structural rationale for the different chromatograph","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-05-18T12:51:12.942Z","creation":"2025-04-06T00:14:32.903Z"},"accession":"S-EPMC9502416","cross_references":{"pubmed":["36144549"],"doi":["10.3390/molecules27185814"]}}