{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Alqahtani MJ"],"pubmed_abstract":["Cisplatin (CP) is a powerful chemotherapeutic agent; however, its therapeutic use is restricted due to its nephrotoxicity. In this work, we profiled the phytoconstituents of <i>Jasminum grandiflorum</i> flower extract (JGF) using LC-MS/MS and explored the possible molecular mechanisms against acute renal failure through pharmacological network analysis. Furthermore, the possible molecular mechanisms of JGF against acute renal failure were verified in an in vivo nephrotoxicity model caused by cisplatin. LC-MS analysis furnished 26 secondary metabolites. Altogether, there were 112 total hit targets for the identified metabolites, among which 55 were potential consensus targets related to nephrotoxicity based on the network pharmacology approach. Upon narrowing the scope to acute renal failur"],"journal":["Metabolites"],"pagination":["792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502427"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic Profiling of <i>Jasminum grandiflorum</i> L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation."],"pmcid":["PMC9502427"],"pubmed_authors":["Negm WA","Mokhtar FA","Tomczyk M","Alqahtani MJ","Mostafa SA","Albogami S","Elhawary S","Batiha GE","Hussein IA"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic Profiling of <i>Jasminum grandiflorum</i> L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation.","description":"Cisplatin (CP) is a powerful chemotherapeutic agent; however, its therapeutic use is restricted due to its nephrotoxicity. In this work, we profiled the phytoconstituents of <i>Jasminum grandiflorum</i> flower extract (JGF) using LC-MS/MS and explored the possible molecular mechanisms against acute renal failure through pharmacological network analysis. Furthermore, the possible molecular mechanisms of JGF against acute renal failure were verified in an in vivo nephrotoxicity model caused by cisplatin. LC-MS analysis furnished 26 secondary metabolites. Altogether, there were 112 total hit targets for the identified metabolites, among which 55 were potential consensus targets related to nephrotoxicity based on the network pharmacology approach. Upon narrowing the scope to acute renal failur","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-04-08T11:55:56.209Z","creation":"2024-11-12T17:41:26.518Z"},"accession":"S-EPMC9502427","cross_references":{"pubmed":["36144196"],"doi":["10.3390/metabo12090792"]}}