{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaw KJ"],"funding":["Gravitas Therapeutics, Inc"],"pagination":["909"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9502624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(9)"],"pubmed_abstract":["GR-2397 (previously VL-2397, ASP2397) is a first-in-class antifungal agent for the treatment of invasive aspergillosis. This siderophore-like molecule resembles ferrichrome; however, it is differentiated by three amino acid changes and an aluminum rather than iron chelate. GR-2397 is transported into fungal cells via the Sit1 transporter, which is not found in humans, leading to fungal specificity. Although the precise mechanism of action is currently unknown, GR-2397 is active against <i>Aspergillus</i> spp. including azole-resistant strains, <i>Fusarium solani</i>, and <i>Candida glabrata</i> in addition to other organisms. Efficacy has been demonstrated in several animal models of invasive aspergillosis, including a 24 h delayed-treatment model where rapid fungicidal activity was observ"],"journal":["Journal of fungi (Basel, Switzerland)"],"pubmed_title":["GR-2397: Review of the Novel Siderophore-like Antifungal Agent for the Treatment of Invasive Aspergillosis."],"pmcid":["PMC9502624"],"funding_grant_id":["Consultant"],"pubmed_authors":["Shaw KJ"],"additional_accession":[]},"is_claimable":false,"name":"GR-2397: Review of the Novel Siderophore-like Antifungal Agent for the Treatment of Invasive Aspergillosis.","description":"GR-2397 (previously VL-2397, ASP2397) is a first-in-class antifungal agent for the treatment of invasive aspergillosis. This siderophore-like molecule resembles ferrichrome; however, it is differentiated by three amino acid changes and an aluminum rather than iron chelate. GR-2397 is transported into fungal cells via the Sit1 transporter, which is not found in humans, leading to fungal specificity. Although the precise mechanism of action is currently unknown, GR-2397 is active against <i>Aspergillus</i> spp. including azole-resistant strains, <i>Fusarium solani</i>, and <i>Candida glabrata</i> in addition to other organisms. Efficacy has been demonstrated in several animal models of invasive aspergillosis, including a 24 h delayed-treatment model where rapid fungicidal activity was observ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-22T00:36:51.15Z","creation":"2025-04-05T19:38:39.856Z"},"accession":"S-EPMC9502624","cross_references":{"pubmed":["36135634"],"doi":["10.3390/jof8090909"]}}