{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen JY"],"funding":["Fujian Provincial Health Technology Project","Natural Science Foundation of Fujian Province","Fundamental Research Project of Fujian Provincial Research Institute for Public Welfare, China"],"pagination":["422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9503253"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Hypertrophic cardiomyopathy (HCM) is a common heritable cardiomyopath. Although considerable effort has been made to understand the pathogenesis of HCM, the mechanism of how long noncoding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network result in HCM remains unknown. In this study, we acquired a total of 520 different expression profiles of lncRNAs (DElncRNAs) and 371 messenger RNAs (mRNA, DEGs) by microarray and 33 microRNAs (DEmiRNAs) by sequencing in plasma of patients with HCM and healthy controls. Then lncRNA-miRNA pairs were predicted using miRcode and starBase and crossed with DEmiRNAs. MiRNA-mRNA pairs were retrieved from miRanda and TargetScan and crossed with DEGs. Combined with these pairs, the ceRNA network with eight lncRNAs, three miRNAs, and 22 mRNAs was con"],"journal":["BMC cardiovascular disorders"],"pubmed_title":["Reconstruction and analysis of potential biomarkers for hypertrophic cardiomyopathy based on a competing endogenous RNA network."],"pmcid":["PMC9503253"],"funding_grant_id":["2020R1011003","No. 2018J01125 and No.2019J01186","No.2018J01125 and No.2019J01186","2019-CX-11"],"pubmed_authors":["Jin JJ","Dai JZ","Xue SJ","Lu LH","Chen JY","Xie ZX","Han JY","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Reconstruction and analysis of potential biomarkers for hypertrophic cardiomyopathy based on a competing endogenous RNA network.","description":"Hypertrophic cardiomyopathy (HCM) is a common heritable cardiomyopath. Although considerable effort has been made to understand the pathogenesis of HCM, the mechanism of how long noncoding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network result in HCM remains unknown. In this study, we acquired a total of 520 different expression profiles of lncRNAs (DElncRNAs) and 371 messenger RNAs (mRNA, DEGs) by microarray and 33 microRNAs (DEmiRNAs) by sequencing in plasma of patients with HCM and healthy controls. Then lncRNA-miRNA pairs were predicted using miRcode and starBase and crossed with DEmiRNAs. MiRNA-mRNA pairs were retrieved from miRanda and TargetScan and crossed with DEGs. Combined with these pairs, the ceRNA network with eight lncRNAs, three miRNAs, and 22 mRNAs was con","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T11:49:59.715Z","creation":"2025-02-19T00:44:02.756Z"},"accession":"S-EPMC9503253","cross_references":{"pubmed":["36138345"],"doi":["10.1186/s12872-022-02862-9"]}}