{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["Guizhou Province Science and Technology Project","National Key Research and Development Program of China"],"pagination":["10484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9503964"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["Sclerotia of <i>Wolfiporia hoelen</i> are one of the most important traditional Chinese medicines and are commonly used in China, Japan, Korea, and other Asian countries. In the present study, we presented the first high-quality homokaryotic genome of <i>W. hoelen</i> with 14 chromosomes which was evaluated with assembly index, telomere position detection, and whole-genome collinearity. A 64.44 Mb genome was assembled with a Contig N50 length of 3.76 Mb. The imbalanced distribution of transposons and chromosome characters revealed the probable two-speed genome of <i>W. hoelen</i>. High consistency between methylation and transposon conserved the genome stability. The expansion of the gene family about signal transduction and nutritional transport has intimate relationships with sclerotial "],"journal":["International journal of molecular sciences"],"pubmed_title":["Homokaryotic High-Quality Genome Assembly of Medicinal Fungi <i>Wolfiporia hoelen</i> Reveals Auto-Regulation and High-Temperature Adaption of Probable Two-Speed Genome."],"pmcid":["PMC9503964"],"funding_grant_id":["2017YFC1703003","QKHZC[2021]249"],"pubmed_authors":["Li S","Dong C","Meng G"],"additional_accession":[]},"is_claimable":false,"name":"Homokaryotic High-Quality Genome Assembly of Medicinal Fungi <i>Wolfiporia hoelen</i> Reveals Auto-Regulation and High-Temperature Adaption of Probable Two-Speed Genome.","description":"Sclerotia of <i>Wolfiporia hoelen</i> are one of the most important traditional Chinese medicines and are commonly used in China, Japan, Korea, and other Asian countries. In the present study, we presented the first high-quality homokaryotic genome of <i>W. hoelen</i> with 14 chromosomes which was evaluated with assembly index, telomere position detection, and whole-genome collinearity. A 64.44 Mb genome was assembled with a Contig N50 length of 3.76 Mb. The imbalanced distribution of transposons and chromosome characters revealed the probable two-speed genome of <i>W. hoelen</i>. High consistency between methylation and transposon conserved the genome stability. The expansion of the gene family about signal transduction and nutritional transport has intimate relationships with sclerotial ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-05-18T12:49:42.594Z","creation":"2025-05-18T12:49:42.594Z"},"accession":"S-EPMC9503964","cross_references":{"pubmed":["36142397"],"doi":["10.3390/ijms231810484"]}}