{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wiley MB"],"funding":["NIDDK NIH HHS","Center for Medicinal Cannabis Research","National Institute of Diabetes and Digestive Kidney Diseases","Center for Medicinal Cannabis Research (CMCR) at the University of California-San Diego"],"pagination":["10549"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9504303"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["The gut barrier provides protection from pathogens and its function is compromised in diet-induced obesity (DIO). The endocannabinoid system in the gut is dysregulated in DIO and participates in gut barrier function; however, whether its activity is protective or detrimental for gut barrier integrity is unclear. We used mice conditionally deficient in cannabinoid receptor subtype-1 (CB<sub>1</sub>R) in the intestinal epithelium (intCB1-/-) to test the hypothesis that CB<sub>1</sub>Rs in intestinal epithelial cells provide protection from diet-induced gut barrier dysfunction. Control and intCB1-/- mice were placed for eight weeks on a high-fat/sucrose Western-style diet (WD) or a low-fat/no-sucrose diet. Endocannabinoid levels and activity of their metabolic enzymes were measured in the lar"],"journal":["International journal of molecular sciences"],"pubmed_title":["Diet-Induced Gut Barrier Dysfunction Is Exacerbated in Mice Lacking Cannabinoid 1 Receptors in the Intestinal Epithelium."],"pmcid":["PMC9504303"],"funding_grant_id":["874959","R01DK119498","Pilot Project 874959","R01 DK119498"],"pubmed_authors":["Wiley MB","DiPatrizio NV"],"additional_accession":[]},"is_claimable":false,"name":"Diet-Induced Gut Barrier Dysfunction Is Exacerbated in Mice Lacking Cannabinoid 1 Receptors in the Intestinal Epithelium.","description":"The gut barrier provides protection from pathogens and its function is compromised in diet-induced obesity (DIO). The endocannabinoid system in the gut is dysregulated in DIO and participates in gut barrier function; however, whether its activity is protective or detrimental for gut barrier integrity is unclear. We used mice conditionally deficient in cannabinoid receptor subtype-1 (CB<sub>1</sub>R) in the intestinal epithelium (intCB1-/-) to test the hypothesis that CB<sub>1</sub>Rs in intestinal epithelial cells provide protection from diet-induced gut barrier dysfunction. Control and intCB1-/- mice were placed for eight weeks on a high-fat/sucrose Western-style diet (WD) or a low-fat/no-sucrose diet. Endocannabinoid levels and activity of their metabolic enzymes were measured in the lar","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T12:00:37.897Z","creation":"2025-02-19T04:38:50.674Z"},"accession":"S-EPMC9504303","cross_references":{"pubmed":["36142461"],"doi":["10.3390/ijms231810549"]}}