biostudies-literatureBinmama SChulalongkorn University through Fundamental Fund 65The Program Management Unit for Human Resources &amp; Institutional Development, Research, and Innovation10951https://www.ebi.ac.uk/biostudies/studies/S-EPMC9505986biostudies-literatureUnknown23(18)Although the impacts of <i>Saccharomyces cerevisiae</i> on cancers are mentioned, data on its use in mice with cyclic GMP-AMP synthase deficiency (cGAS-/-) are even rarer. Here, 12 weeks of oral administration of <i>S. cerevisiae</i> protected cGAS-/- mice from azoxymethane (AOM)-induced colon cancers, partly through dysbiosis attenuation (fecal microbiome analysis). In parallel, a daily intralesional injection of a whole glucan particle (WGP; the beta-glucan extracted from <i>S. cerevisiae</i>) attenuated the growth of subcutaneous tumor using MC38 (murine colon cancer cell line) in cGAS-/- mice. Interestingly, the incubation of fluorescent-stained MC38 with several subtypes of macrophages, including M1 (using Lipopolysaccharide; LPS), M2 (IL-4), and tumor-associated macrophages (TAM; usiInternational journal of molecular sciencesBeta-Glucan from <i>S. cerevisiae</i> Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy.PMC9505986B16F640175 and B05F640144CUFRB65_hea [33] _040_30_21Cheibchalard THiengrach PChindamporn ABinmama SPisitkun PVisitchanakun PDang CPSomboonna NLeelahavanichkul AfalseBeta-Glucan from <i>S. cerevisiae</i> Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy.Although the impacts of <i>Saccharomyces cerevisiae</i> on cancers are mentioned, data on its use in mice with cyclic GMP-AMP synthase deficiency (cGAS-/-) are even rarer. Here, 12 weeks of oral administration of <i>S. cerevisiae</i> protected cGAS-/- mice from azoxymethane (AOM)-induced colon cancers, partly through dysbiosis attenuation (fecal microbiome analysis). In parallel, a daily intralesional injection of a whole glucan particle (WGP; the beta-glucan extracted from <i>S. cerevisiae</i>) attenuated the growth of subcutaneous tumor using MC38 (murine colon cancer cell line) in cGAS-/- mice. Interestingly, the incubation of fluorescent-stained MC38 with several subtypes of macrophages, including M1 (using Lipopolysaccharide; LPS), M2 (IL-4), and tumor-associated macrophages (TAM; usi2022-01-01T00:00:00Z2022 Sep2025-05-29T20:02:58.243Z2025-05-29T20:02:58.243ZS-EPMC95059863614285910.3390/ijms231810951