{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim S"],"funding":["The National Research Foundation of Korea (NRF)"],"pagination":["10683"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9506180"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["<i>Staphylococcus aureus</i> is one of the major pathogens responsible for antimicrobial resistance-associated death. <i>S. aureus</i> can secrete various exotoxins, and staphylococcal biofilms play critical roles in antibiotic tolerance and the persistence of chronic infections. Here, we investigated the inhibitory effects of 18 hydroquinones on biofilm formation and virulence factor production by <i>S. aureus</i>. It was found that 2,5-bis(1,1,3,3-tetramethylbutyl) hydroquinone (TBHQ) at 1 µg/mL efficiently inhibits biofilm formation by two methicillin-sensitive and two methicillin-resistant <i>S. aureus</i> strains with MICs of 5 µg/mL, whereas the backbone compound hydroquinone did not (MIC &gt; 400 µg/mL). In addition, 2,3-dimethylhydroquinone and <i>tert</i>-butylhydroquinone at 50 µg/mL also exhibited antibiofilm activity. TBHQ at 1 µg/mL significantly decreased the hemolytic effect and lipase production by <i>S. aureus</i>, and at 5-50 µg/mL was non-toxic to the nematode <i>Caenorhabditis elegans</i> and did not adversely affect <i>Brassica rapa</i> seed germination or growth. Transcriptional analyses showed that TBHQ suppressed the expression of <i>RNAIII</i> (effector of quorum sensing). These results suggest that hydroquinones, particularly TBHQ, are potentially useful for inhibiting <i>S. aureus</i> biofilm formation and virulence."],"journal":["International journal of molecular sciences"],"pubmed_title":["Hydroquinones Inhibit Biofilm Formation and Virulence Factor Production in <i>Staphylococcus aureus</i>."],"pmcid":["PMC9506180"],"funding_grant_id":["2021R1A2C1008368","2021R1I1A3A04037486","2014R1A6A1031189"],"pubmed_authors":["Kim S","Tan Y","Lee J","Kim YG","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Hydroquinones Inhibit Biofilm Formation and Virulence Factor Production in <i>Staphylococcus aureus</i>.","description":"<i>Staphylococcus aureus</i> is one of the major pathogens responsible for antimicrobial resistance-associated death. <i>S. aureus</i> can secrete various exotoxins, and staphylococcal biofilms play critical roles in antibiotic tolerance and the persistence of chronic infections. Here, we investigated the inhibitory effects of 18 hydroquinones on biofilm formation and virulence factor production by <i>S. aureus</i>. It was found that 2,5-bis(1,1,3,3-tetramethylbutyl) hydroquinone (TBHQ) at 1 µg/mL efficiently inhibits biofilm formation by two methicillin-sensitive and two methicillin-resistant <i>S. aureus</i> strains with MICs of 5 µg/mL, whereas the backbone compound hydroquinone did not (MIC &gt; 400 µg/mL). In addition, 2,3-dimethylhydroquinone and <i>tert</i>-butylhydroquinone at 50 µg/mL also exhibited antibiofilm activity. TBHQ at 1 µg/mL significantly decreased the hemolytic effect and lipase production by <i>S. aureus</i>, and at 5-50 µg/mL was non-toxic to the nematode <i>Caenorhabditis elegans</i> and did not adversely affect <i>Brassica rapa</i> seed germination or growth. Transcriptional analyses showed that TBHQ suppressed the expression of <i>RNAIII</i> (effector of quorum sensing). These results suggest that hydroquinones, particularly TBHQ, are potentially useful for inhibiting <i>S. aureus</i> biofilm formation and virulence.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T07:28:05.263Z","creation":"2025-04-19T07:28:05.263Z"},"accession":"S-EPMC9506180","cross_references":{"pubmed":["36142597"],"doi":["10.3390/ijms231810683"]}}