biostudies-literatureUnknown56(5)Hemrom A<h4>Purpose</h4>Neuroblastoma (NB) is childhood's most common extracranial solid malignancy. We have compared two imaging modalities, ¹³¹I-MIBG and ¹⁸F-DOPA PET/CT, to evaluate NB. Also, feasibility of the application of standardised scoring systems, SIOPEN and Curie scoring systems, in ¹⁸F-DOPA PET/CT was explored.<h4>Methods</h4>Patients with histopathology-proven NB underwent ¹³¹I-MIBG (planar and SPECT/CT) and ¹⁸F-DOPA PET/CT scans, as per standard imaging protocols. Duration between scans ranged from 1 to 30 days (median = 8 days). Number of lesions in Curie and SIOPEN scoring systems applied on both modalities was compared.<h4>Results</h4>Forty-six patients were included (M:F = 29:17) with a median age of 36 months. Both <sup>131Nuclear medicine and molecular imaging236-244https://www.ebi.ac.uk/biostudies/studies/S-EPMC9508302biostudies-literatureComparative Role of ¹⁸F-DOPA PET/CT and ¹³¹I-MIBG Scintigraphy in Neuroblastoma and Application of Curie and SIOPEN Scoring Systems in ¹⁸F-DOPA PET/CT.PMC9508302Hemrom ADamle NAArora GBal CfalseComparative Role of ¹⁸F-DOPA PET/CT and ¹³¹I-MIBG Scintigraphy in Neuroblastoma and Application of Curie and SIOPEN Scoring Systems in ¹⁸F-DOPA PET/CT.<h4>Purpose</h4>Neuroblastoma (NB) is childhood's most common extracranial solid malignancy. We have compared two imaging modalities, ¹³¹I-MIBG and ¹⁸F-DOPA PET/CT, to evaluate NB. Also, feasibility of the application of standardised scoring systems, SIOPEN and Curie scoring systems, in ¹⁸F-DOPA PET/CT was explored.<h4>Methods</h4>Patients with histopathology-proven NB underwent ¹³¹I-MIBG (planar and SPECT/CT) and ¹⁸F-DOPA PET/CT scans, as per standard imaging protocols. Duration between scans ranged from 1 to 30 days (median = 8 days). Number of lesions in Curie and SIOPEN scoring systems applied on both modalities was compared.<h4>Results</h4>Forty-six patients were included (M:F = 29:17) with a median age of 36 months. Both <sup>1312022-01-01T00:00:00Z2022 Oct2025-04-25T21:23:25.585Z2025-04-06T08:45:50.19ZS-EPMC95083023631083410.1007/s13139-022-00762-6