biostudies-literatureUnknown16(5)Wang HWe comprehensively studied directional feedback and feedforward connectivity to explore potential connectivity changes that underlie propofol-induced deep sedation. We further investigated the corticocortical connectivity patterns within and between hemispheres. Sixty-channel electroencephalographic data were collected from 19 healthy volunteers in a resting wakefulness state and propofol-induced deep unconsciousness state defined by a bispectral index value of 40. A source analysis was employed to locate cortical activity. The Desikan-Killiany atlas was used to partition cortices, and directional functional connectivity was assessed by normalized symbolic transfer entropy between higher-order (prefrontal and frontal) and lower-order (auditory, sensorimotor and visual) cortices and betweenCognitive neurodynamics1029-1043https://www.ebi.ac.uk/biostudies/studies/S-EPMC9508318biostudies-literatureSelective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers.PMC9508318Cai SWang QZhang YSong DWang HHuang LWang YCheng HYan FfalseSelective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers.We comprehensively studied directional feedback and feedforward connectivity to explore potential connectivity changes that underlie propofol-induced deep sedation. We further investigated the corticocortical connectivity patterns within and between hemispheres. Sixty-channel electroencephalographic data were collected from 19 healthy volunteers in a resting wakefulness state and propofol-induced deep unconsciousness state defined by a bispectral index value of 40. A source analysis was employed to locate cortical activity. The Desikan-Killiany atlas was used to partition cortices, and directional functional connectivity was assessed by normalized symbolic transfer entropy between higher-order (prefrontal and frontal) and lower-order (auditory, sensorimotor and visual) cortices and between2022-01-01T00:00:00Z2022 Oct2025-04-05T09:42:40.04Z2025-04-05T09:42:40.04ZS-EPMC95083183623741010.1007/s11571-021-09775-x