biostudies-literatureHalloran CMCancer Research UKNational Institute for Health Research (NIHR)e198https://www.ebi.ac.uk/biostudies/studies/S-EPMC9508971biostudies-literatureUnknown3(3)Whether a Blumgart anastomosis (BA) is superior to Cattell-Warren anastomosis (CWA) in terms of postoperative pancreatic fistula (POPF) following pancreatoduodenectomy.<h4>Importance</h4>Complications driven by POPF following pancreatic cancer resection may hinder adjuvant therapy, shortening survival. BA may reduce complications compared to CWA, improving the use of adjuvant therapy and prolonging survival.<h4>Methods</h4>A multicenter double-blind, controlled trial of patients undergoing resection for suspected pancreatic head cancer, randomized during surgery to a BA or CWA, stratified by pancreatic consistency and duct diameter. The primary end point was POPF, and secondary outcome measures were adjuvant therapy use, specified surgical complications, quality of life, and survival from Annals of surgery open : perspectives of surgical history, education, and clinical approachesA Multicenter, Randomized, Double-Blinded, Clinical Trial Comparing Cattell-Warren and Blumgart Anastomoses Following Partial Pancreatoduodenectomy: PANasta Trial.PMC950897116186167911768008/29/028968118831595716812A16791Psarelli EEJackson RSmith AHalloran CMPausch TMGomez DO'Reilly DAPrachalias AReddy SNeoptolemos JPDavidson BPlatt KGhaneh PfalseA Multicenter, Randomized, Double-Blinded, Clinical Trial Comparing Cattell-Warren and Blumgart Anastomoses Following Partial Pancreatoduodenectomy: PANasta Trial.Whether a Blumgart anastomosis (BA) is superior to Cattell-Warren anastomosis (CWA) in terms of postoperative pancreatic fistula (POPF) following pancreatoduodenectomy.<h4>Importance</h4>Complications driven by POPF following pancreatic cancer resection may hinder adjuvant therapy, shortening survival. BA may reduce complications compared to CWA, improving the use of adjuvant therapy and prolonging survival.<h4>Methods</h4>A multicenter double-blind, controlled trial of patients undergoing resection for suspected pancreatic head cancer, randomized during surgery to a BA or CWA, stratified by pancreatic consistency and duct diameter. The primary end point was POPF, and secondary outcome measures were adjuvant therapy use, specified surgical complications, quality of life, and survival from 2022-01-01T00:00:00Z2022 Sep2026-05-31T22:55:39.858Z2024-11-15T00:40:35.275ZS-EPMC95089713619949010.1097/AS9.0000000000000198