{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arima K"],"funding":["Cancer Research UK","NIDDK NIH HHS","NCI NIH HHS"],"pagination":["862-874"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9509428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["163(4)"],"pubmed_abstract":["<h4>Background & aims</h4>Evidence supports a carcinogenic role of Escherichia coli carrying the pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of the Western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks<sup>+</sup>E coli.<h4>Methods</h4>Western diet score was calculated using food frequency questionnaire data obtained every 4 years during follow-up of 134,775 participants in 2 United States-wide prospective cohort studies. Using quantitative polymerase chain reaction, we measured pks<sup>+</sup>E coli DNA in 1175 tumors among 3200 incident colorectal cancer cases that had occurred during the follow-up. We used the 3200 cases and inverse probabili"],"journal":["Gastroenterology"],"pubmed_title":["Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies."],"pmcid":["PMC9509428"],"funding_grant_id":["K07 CA188126","R35 CA197735","U01 CA167552","K24 DK098311","R01 CA137178","P01 CA087969","K07 CA190673","27140","UM1 CA167552","R01 CA118553","R35 CA253185","R01 CA151993","P01 CA055075","P50 CA127003","R01 CA169141","P30 DK043351","UM1 CA186107"],"pubmed_authors":["Wu K","Kosumi K","Sears CL","Willett WC","Giovannucci EL","Shi S","Wang F","Lau MC","Vayrynen JP","Arima K","Zhao M","Ogata Y","Song M","Akimoto N","Fujiyoshi K","Haruki K","Okadome K","Baba H","Chan AT","Giannakis M","Twombly TS","Huttenhower C","Ugai T","Kishikawa J","Ogino S","Mehta RS","Zhong R","Zhang X","Fuchs CS","Garrett WS","Meyerhardt JA","Nowak JA"],"additional_accession":[]},"is_claimable":false,"name":"Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.","description":"<h4>Background & aims</h4>Evidence supports a carcinogenic role of Escherichia coli carrying the pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of the Western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks<sup>+</sup>E coli.<h4>Methods</h4>Western diet score was calculated using food frequency questionnaire data obtained every 4 years during follow-up of 134,775 participants in 2 United States-wide prospective cohort studies. Using quantitative polymerase chain reaction, we measured pks<sup>+</sup>E coli DNA in 1175 tumors among 3200 incident colorectal cancer cases that had occurred during the follow-up. We used the 3200 cases and inverse probabili","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T23:53:28.029Z","creation":"2025-04-07T11:13:24.666Z"},"accession":"S-EPMC9509428","cross_references":{"pubmed":["35760086"],"doi":["10.1053/j.gastro.2022.06.054"]}}