biostudies-literatureUnknown9(1)Hemmingsson JVetenskapsrådetUniversity of GothenburgStiftelsen Konung Gustaf V:s JubileumsfondCancerfonden<h4>Background</h4>Based on theoretical and preclinical results, terbium-161 may be a valid alternative to lutetium-177 and yttrium-90 in radionuclide therapies. The large low-energy electron emission from terbium-161 is a favorable feature in the treatment of disseminated disease, but its impact on the radiosensitive bone marrow needs to be evaluated. Using voxel-based skeletal dosimetry models in which active bone marrow is defined as regions containing stem cells and progenitor cells of the hematopoietic lineage, we generated S-values (absorbed dose per decay) for terbium-161 and evaluated its distribution-dependence in bone marrow cavities.<h4>Methods</h4>S-values in the active bone marrow were calculated for terbium-161, lutetium-177, and yttrium-90 irradiation using two (male/female)EJNMMI physics65https://www.ebi.ac.uk/biostudies/studies/S-EPMC9509518biostudies-literatureActive bone marrow S-values for the low-energy electron emitter terbium-161 compared to S-values for lutetium-177 and yttrium-90.PMC9509518Hemmingsson JSvensson Jvan der Meulen NPBernhardt PMuller CfalseActive bone marrow S-values for the low-energy electron emitter terbium-161 compared to S-values for lutetium-177 and yttrium-90.<h4>Background</h4>Based on theoretical and preclinical results, terbium-161 may be a valid alternative to lutetium-177 and yttrium-90 in radionuclide therapies. The large low-energy electron emission from terbium-161 is a favorable feature in the treatment of disseminated disease, but its impact on the radiosensitive bone marrow needs to be evaluated. Using voxel-based skeletal dosimetry models in which active bone marrow is defined as regions containing stem cells and progenitor cells of the hematopoietic lineage, we generated S-values (absorbed dose per decay) for terbium-161 and evaluated its distribution-dependence in bone marrow cavities.<h4>Methods</h4>S-values in the active bone marrow were calculated for terbium-161, lutetium-177, and yttrium-90 irradiation using two (male/female)2022-01-01T00:00:00Z2022 Sep2025-05-29T19:25:33.054Z2025-05-29T19:25:33.054ZS-EPMC95095183615338610.1186/s40658-022-00495-7