biostudies-literatureUnknown13Han L<h4>Background</h4>Neuromyelitis optica spectrum disorder (NMOSD) often leads to disability and exerts a heavy toll on the work and life of affected female patients. This study aimed to analyze the current employment situation and economic burden as well as the risk factors for unemployment in female patients with NMSOD.<h4>Methods</h4>We compared the following unemployment- and employment-related aspects in with NSMOD, which were investigated using questionnaires: the specific impact of NMOSD on work, medical expenses, and factors affecting unemployment.<h4>Results</h4>We enrolled 351 female patients with NMOSD. More than half (54.1%, 190/351) of participants reported that the disease led to unemployment. The unemployment group was significantly older (46.9 ± 12.1 years vs. 39.3 ± 9.4 yeaFrontiers in neurology973163https://www.ebi.ac.uk/biostudies/studies/S-EPMC9510986biostudies-literatureNeuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women.PMC9510986Han LWan YCai LHong PShi ZWang JLang YZhou HfalseNeuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women.<h4>Background</h4>Neuromyelitis optica spectrum disorder (NMOSD) often leads to disability and exerts a heavy toll on the work and life of affected female patients. This study aimed to analyze the current employment situation and economic burden as well as the risk factors for unemployment in female patients with NMSOD.<h4>Methods</h4>We compared the following unemployment- and employment-related aspects in with NSMOD, which were investigated using questionnaires: the specific impact of NMOSD on work, medical expenses, and factors affecting unemployment.<h4>Results</h4>We enrolled 351 female patients with NMOSD. More than half (54.1%, 190/351) of participants reported that the disease led to unemployment. The unemployment group was significantly older (46.9 ± 12.1 years vs. 39.3 ± 9.4 yea2022-01-01T00:00:00Z20222025-04-19T21:54:11.938Z2025-04-19T21:54:11.938ZS-EPMC95109863617203310.3389/fneur.2022.973163