biostudies-literaturePiewbang CThailand Science Research and InnovationThe Second Century Fund (C2F), Chulalongkorn UniversityRatchadapisek Somphot Fund for Postdoctoral Fellowship, Chulalongkorn UniversityNational Research Council of ThailandThailand Research FundJoint Funding of External Research Project, Ratchadaphiseksomphot Endowment Fund and Veterinary Science Research FundThailand Science Research and Innovation Fund (TSRI)1648-1659https://www.ebi.ac.uk/biostudies/studies/S-EPMC9511090biostudies-literatureUnknown36(5)<h4>Background</h4>Whether domestic cat hepadnavirus (DCH) infection is associated with clinical disease remains to be determined.<h4>Objectives</h4>To determine the relationship between DCH detection, hematology, serum bichemistry and liver histology in DCH-positive cats.<h4>Animals</h4>One thousand twenty-two cats in Thailand without concurrent diseases and not undergoing treatments adversely affecting the liver.<h4>Methods</h4>Retrospective cross-sectional study. Samples derived from cats with concurrent virus detection were excluded. DCH detection was determined in blood and fresh-frozen liver by quantitative polymerase chain reaction (qPCR) and further investigated in liver sections showing histological parenchymal disorders (HPD) and normal liver (HNL) using in situ hybridization (ISJournal of veterinary internal medicineDomestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study.PMC9511090PHD/0021/256NRCT5-RGJ63001-013CU_FRB640001_01_31_2NRCT5‐RGJ63001‐013N42A650553N41A640175RES_65_005_31_005Piewbang CTummaruk PDankaona WYostawonkul JSirivisoot SPoonsin PKasantikul TLacharoje STechangamsuwan SfalseDomestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study.<h4>Background</h4>Whether domestic cat hepadnavirus (DCH) infection is associated with clinical disease remains to be determined.<h4>Objectives</h4>To determine the relationship between DCH detection, hematology, serum bichemistry and liver histology in DCH-positive cats.<h4>Animals</h4>One thousand twenty-two cats in Thailand without concurrent diseases and not undergoing treatments adversely affecting the liver.<h4>Methods</h4>Retrospective cross-sectional study. Samples derived from cats with concurrent virus detection were excluded. DCH detection was determined in blood and fresh-frozen liver by quantitative polymerase chain reaction (qPCR) and further investigated in liver sections showing histological parenchymal disorders (HPD) and normal liver (HNL) using in situ hybridization (IS2022-01-01T00:00:00Z2022 Sep2026-07-14T17:11:14.803Z2025-02-19T01:21:30.295ZS-EPMC95110903605464210.1111/jvim.16525