biostudies-literatureUnknown10(17)Lin P<h4>Background</h4>Head and neck squamous cell carcinoma (HNSC) is the 7th most common type of cancer in the world. Through the advantages of The Cancer Genome Atlas (TCGA) large-scale sequencing-based genome analysis technology, we can explore the potential molecular mechanisms that can improve the prognosis of HNSC patients.<h4>Methods</h4>The HNSC transcriptome and clinical data were downloaded from TCGA database. A univariate survival analysis and differential expression analysis were conducted to obtain the intersection gene set. A protein-protein interaction (PPI) analysis, modular analysis, and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were then conducted to identify the hub genes. Clinical correlation analysis, univariate and mAnnals of translational medicine923https://www.ebi.ac.uk/biostudies/studies/S-EPMC9511182biostudies-literaturePrognostic value of CD247 in patients with head and neck squamous cell carcinoma: bioinformatic analysis of TCGA database.PMC9511182Lin PDing YWang QYLiu MYYe JCHu XLHu YYfalsePrognostic value of CD247 in patients with head and neck squamous cell carcinoma: bioinformatic analysis of TCGA database.<h4>Background</h4>Head and neck squamous cell carcinoma (HNSC) is the 7th most common type of cancer in the world. Through the advantages of The Cancer Genome Atlas (TCGA) large-scale sequencing-based genome analysis technology, we can explore the potential molecular mechanisms that can improve the prognosis of HNSC patients.<h4>Methods</h4>The HNSC transcriptome and clinical data were downloaded from TCGA database. A univariate survival analysis and differential expression analysis were conducted to obtain the intersection gene set. A protein-protein interaction (PPI) analysis, modular analysis, and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis were then conducted to identify the hub genes. Clinical correlation analysis, univariate and m2022-01-01T00:00:00Z2022 Sep2026-05-28T01:09:25.347Z2025-04-19T22:48:55.221ZS-EPMC95111823617208910.21037/atm-22-1143