{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(10)"],"submitter":["Lin CK"],"pubmed_abstract":["<h4>Background</h4>Tissue oedema affects tissue perfusion and interferes with the monitoring of tissue oxygenation in patients with severe sepsis. However, the underlying mechanisms remain unclear. We used a wireless near-infrared spectroscopy (NIRS) device that transmits tri-wavelength light to quantify tissue haemoglobin (Hb) and water (H<sub>2</sub>O) content. We estimated tissue H<sub>2</sub>O in severe sepsis patients and healthy controls, compared their difference, and investigated the correlation of tissue H<sub>2</sub>O with systemic haemodynamics and its impact on tissue oxygenation.<h4>Methods</h4>Seventy-seven adult patients with new-onset severe sepsis admitted to the intensive care unit within 72 h and 30 healthy volunteers (controls) were enrolled. The NIRS device was placed "],"journal":["Quantitative imaging in medicine and surgery"],"pagination":["4953-4967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9511429"],"repository":["biostudies-literature"],"pubmed_title":["Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study."],"pmcid":["PMC9511429"],"pubmed_authors":["Hung MS","Ho MC","Tsai YH","Huang SY","Lin BS","Lee WC","Chang CC","Lin CM","Chen MC","Lin YC","Li JR","Lin CK","Leu SW","Zhou SK"],"additional_accession":[]},"is_claimable":false,"name":"Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study.","description":"<h4>Background</h4>Tissue oedema affects tissue perfusion and interferes with the monitoring of tissue oxygenation in patients with severe sepsis. However, the underlying mechanisms remain unclear. We used a wireless near-infrared spectroscopy (NIRS) device that transmits tri-wavelength light to quantify tissue haemoglobin (Hb) and water (H<sub>2</sub>O) content. We estimated tissue H<sub>2</sub>O in severe sepsis patients and healthy controls, compared their difference, and investigated the correlation of tissue H<sub>2</sub>O with systemic haemodynamics and its impact on tissue oxygenation.<h4>Methods</h4>Seventy-seven adult patients with new-onset severe sepsis admitted to the intensive care unit within 72 h and 30 healthy volunteers (controls) were enrolled. The NIRS device was placed ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-21T19:01:17.8Z","creation":"2025-04-05T17:26:13.704Z"},"accession":"S-EPMC9511429","cross_references":{"pubmed":["36185059"],"doi":["10.21037/qims-22-127"]}}