biostudies-literatureUnknown12(10)Lin CK<h4>Background</h4>Tissue oedema affects tissue perfusion and interferes with the monitoring of tissue oxygenation in patients with severe sepsis. However, the underlying mechanisms remain unclear. We used a wireless near-infrared spectroscopy (NIRS) device that transmits tri-wavelength light to quantify tissue haemoglobin (Hb) and water (H₂O) content. We estimated tissue H₂O in severe sepsis patients and healthy controls, compared their difference, and investigated the correlation of tissue H₂O with systemic haemodynamics and its impact on tissue oxygenation.<h4>Methods</h4>Seventy-seven adult patients with new-onset severe sepsis admitted to the intensive care unit within 72 h and 30 healthy volunteers (controls) were enrolled. The NIRS device was placed Quantitative imaging in medicine and surgery4953-4967https://www.ebi.ac.uk/biostudies/studies/S-EPMC9511429biostudies-literatureIncreased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study.PMC9511429Hung MSHo MCTsai YHHuang SYLin BSLee WCChang CCLin CMChen MCLin YCLi JRLin CKLeu SWZhou SKfalseIncreased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study.<h4>Background</h4>Tissue oedema affects tissue perfusion and interferes with the monitoring of tissue oxygenation in patients with severe sepsis. However, the underlying mechanisms remain unclear. We used a wireless near-infrared spectroscopy (NIRS) device that transmits tri-wavelength light to quantify tissue haemoglobin (Hb) and water (H₂O) content. We estimated tissue H₂O in severe sepsis patients and healthy controls, compared their difference, and investigated the correlation of tissue H₂O with systemic haemodynamics and its impact on tissue oxygenation.<h4>Methods</h4>Seventy-seven adult patients with new-onset severe sepsis admitted to the intensive care unit within 72 h and 30 healthy volunteers (controls) were enrolled. The NIRS device was placed 2022-01-01T00:00:00Z2022 Oct2025-04-21T19:01:17.8Z2025-04-05T17:26:13.704ZS-EPMC95114293618505910.21037/qims-22-127