biostudies-literatureUnknown14(17)Lee CC<h4>Background</h4>Nicorandil will activate ATP-sensitive potassium channel (KATP). However, activation of potassium channels plays an important role in the mechanism of atrial fibrillation (AF) or atrial flutter (AFL). Whether use of nicorandil might contribute to initiation and/or perpetuation of AF/AFL remained unknown. We determined the relationship between use of nicorandil and risk of atrial fibrillation and determined its molecular mechanism.<h4>Methods</h4>We performed a nested case-control study using a cohort from the National Health Insurance Research Database (NHIRD) of Taiwan. The association between nicorandil use and risk of atrial fibrillation/flutter was estimated by logistic regression model. We also performed molecular, cellular and animal studies to explain the associatAging6975-6992https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512508biostudies-literatureUse of nicorandil is associated with increased risk of incident atrial fibrillation.PMC9512508Hsu WTTehrani BLiu SSTsai CTChan CYHuang PSHwang JJLee CCHuang TYChen JJChang SNfalseUse of nicorandil is associated with increased risk of incident atrial fibrillation.<h4>Background</h4>Nicorandil will activate ATP-sensitive potassium channel (KATP). However, activation of potassium channels plays an important role in the mechanism of atrial fibrillation (AF) or atrial flutter (AFL). Whether use of nicorandil might contribute to initiation and/or perpetuation of AF/AFL remained unknown. We determined the relationship between use of nicorandil and risk of atrial fibrillation and determined its molecular mechanism.<h4>Methods</h4>We performed a nested case-control study using a cohort from the National Health Insurance Research Database (NHIRD) of Taiwan. The association between nicorandil use and risk of atrial fibrillation/flutter was estimated by logistic regression model. We also performed molecular, cellular and animal studies to explain the associat2022-01-01T00:00:00Z2022 Sep2025-04-04T20:19:41.856Z2025-04-04T20:19:41.856ZS-EPMC95125083608495010.18632/aging.204259