{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(9)"],"submitter":["Zhang C"],"pubmed_abstract":["<h4>Objectives</h4>Although adoptive cell therapy with T-cell receptor-engineered T cells (TCR-Ts) has mediated effective antitumor responses in several cancers, senescence of T cells could impair the therapeutic effect of TCR-Ts. Thus, it is essential to elucidate the characteristics of senescent TCR-Ts and how to subsequently improve their antitumor effect. Here, we focused on the influence of autophagy on TCR-Ts, since autophagy is tightly associated with the regulation of T-cell activation, proliferation and differentiation.<h4>Methods</h4>We first evaluated autophagy level of senescent TCR-Ts, and then the senescent TCR-Ts were expanded <i>in vitro</i> for 7 days with and without spermidine treatment, respectively. Furthermore, the proliferative potential, phenotypical characteristics"],"journal":["Clinical & translational immunology"],"pagination":["e1419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512689"],"repository":["biostudies-literature"],"pubmed_title":["Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells."],"pmcid":["PMC9512689"],"pubmed_authors":["Shen L","Li S","Zhou P","Xiao Y","Lu Z","Teng X","Zhang C","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells.","description":"<h4>Objectives</h4>Although adoptive cell therapy with T-cell receptor-engineered T cells (TCR-Ts) has mediated effective antitumor responses in several cancers, senescence of T cells could impair the therapeutic effect of TCR-Ts. Thus, it is essential to elucidate the characteristics of senescent TCR-Ts and how to subsequently improve their antitumor effect. Here, we focused on the influence of autophagy on TCR-Ts, since autophagy is tightly associated with the regulation of T-cell activation, proliferation and differentiation.<h4>Methods</h4>We first evaluated autophagy level of senescent TCR-Ts, and then the senescent TCR-Ts were expanded <i>in vitro</i> for 7 days with and without spermidine treatment, respectively. Furthermore, the proliferative potential, phenotypical characteristics","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T03:38:28.804Z","creation":"2025-04-05T20:46:31.698Z"},"accession":"S-EPMC9512689","cross_references":{"pubmed":["36188121"],"doi":["10.1002/cti2.1419"]}}