{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blanco-Obregon D"],"funding":["European Research Council"],"pagination":["5629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The control of organ size mainly relies on precise autonomous growth programs. However, organ development is subject to random variations, called developmental noise, best revealed by the fluctuating asymmetry observed between bilateral organs. The developmental mechanisms ensuring bilateral symmetry in organ size are mostly unknown. In Drosophila, null mutations for the relaxin-like hormone Dilp8 increase wing fluctuating asymmetry, suggesting that Dilp8 plays a role in buffering developmental noise. Here we show that size adjustment of the wing primordia involves a peak of dilp8 expression that takes place sharply at the end of juvenile growth. Wing size adjustment relies on a cross-organ communication involving the epidermis as the source of Dilp8. We identify ecdysone signaling as both"],"journal":["Nature communications"],"pubmed_title":["A Dilp8-dependent time window ensures tissue size adjustment in Drosophila."],"pmcid":["PMC9512784"],"funding_grant_id":["694677"],"pubmed_authors":["Andersen DS","Blanco-Obregon D","Colombani J","Brutscher F","Leopold P","Narasimha S","McCusker D","El Marzkioui K","Boulan L","Valzania L","Kapoor V"],"additional_accession":[]},"is_claimable":false,"name":"A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.","description":"The control of organ size mainly relies on precise autonomous growth programs. However, organ development is subject to random variations, called developmental noise, best revealed by the fluctuating asymmetry observed between bilateral organs. The developmental mechanisms ensuring bilateral symmetry in organ size are mostly unknown. In Drosophila, null mutations for the relaxin-like hormone Dilp8 increase wing fluctuating asymmetry, suggesting that Dilp8 plays a role in buffering developmental noise. Here we show that size adjustment of the wing primordia involves a peak of dilp8 expression that takes place sharply at the end of juvenile growth. Wing size adjustment relies on a cross-organ communication involving the epidermis as the source of Dilp8. We identify ecdysone signaling as both","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-26T22:02:43.71Z","creation":"2025-04-06T17:06:07.825Z"},"accession":"S-EPMC9512784","cross_references":{"pubmed":["36163439"],"doi":["10.1038/s41467-022-33387-6"]}}