{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Tsugeno Y"],"pubmed_abstract":["The objective of the current study was to examine the effects of fibroblast growth factor-2 (FGF-2) on conjunctival fibrogenesis that was induced by the presence of transforming growth factor-β2 (TGF-β2). Two-dimension (2D) and three-dimension (3D) cultured human conjunctival fibroblasts (HconF) were used for this purpose. The 2D and 3D cultured HconF were characterized by transendothelial electrical resistance (TEER) and FITC dextran permeability measurements (2D), real-time metabolic analyses (2D), size and stiffness measurements (3D), and the mRNA expression of extracellular matrix molecules, their modulators, Tissue inhibitor of metalloproteinases and matrix metalloproteinases and ER-stress related genes (2D and 3D). FGF-2 significantly increased planar proliferation, as evidenced by T"],"journal":["Scientific reports"],"pagination":["16006"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512844"],"repository":["biostudies-literature"],"pubmed_title":["FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts."],"pmcid":["PMC9512844"],"pubmed_authors":["Sato T","Suzuki S","Ohguro H","Tsugeno Y","Furuhashi M","Umetsu A","Watanabe M","Hikage F","Ida Y"],"additional_accession":[]},"is_claimable":false,"name":"FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts.","description":"The objective of the current study was to examine the effects of fibroblast growth factor-2 (FGF-2) on conjunctival fibrogenesis that was induced by the presence of transforming growth factor-β2 (TGF-β2). Two-dimension (2D) and three-dimension (3D) cultured human conjunctival fibroblasts (HconF) were used for this purpose. The 2D and 3D cultured HconF were characterized by transendothelial electrical resistance (TEER) and FITC dextran permeability measurements (2D), real-time metabolic analyses (2D), size and stiffness measurements (3D), and the mRNA expression of extracellular matrix molecules, their modulators, Tissue inhibitor of metalloproteinases and matrix metalloproteinases and ER-stress related genes (2D and 3D). FGF-2 significantly increased planar proliferation, as evidenced by T","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:24:41.705Z","creation":"2025-04-05T21:42:38.825Z"},"accession":"S-EPMC9512844","cross_references":{"pubmed":["36163231"],"doi":["10.1038/s41598-022-20036-7"]}}