{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sawanaka Y"],"funding":["MEXT | Japan Society for the Promotion of Science","MEXT | Japan Society for the Promotion of Science (JSPS)","Yoshinori Ohsumi Fund for Fundamental Research"],"pagination":["5648"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512892"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Self-complementary assembly is one of the most promising phenomena for the formation of discrete assemblies, e.g., proteins and capsids. However, self-complementary assembly based on multiple host-guest systems has been scarcely reported due to the difficulty in controlling each assembly. Herein, we report a dual interaction system in which the key assembly direction is well regulated by both π-π stacking and hydrogen bonding to construct a self-complementary macrocycle. Continuous host-guest behavior of anthracene-based molecular tweezers during crystallization leads to successful construction of a cyclic hexamer, which is reminiscent of Kekulé's monkey model. Furthermore, the cyclic hexamer in a tight and triple-layered fashion shows hierarchical assembly into cuboctahedron and rhombohedral assemblies in the presence of trifluoroacetic acid. Our findings would be potentially one of metal-free strategies for constructing anthracene-based supramolecular assemblies with higher-order structure."],"journal":["Nature communications"],"pubmed_title":["A self-complementary macrocycle by a dual interaction system."],"pmcid":["PMC9512892"],"funding_grant_id":["JP19K23623","JP20H02721","JP20K15255"],"pubmed_authors":["Yamashina M","Toyota S","Ohtsu H","Sawanaka Y"],"additional_accession":[]},"is_claimable":false,"name":"A self-complementary macrocycle by a dual interaction system.","description":"Self-complementary assembly is one of the most promising phenomena for the formation of discrete assemblies, e.g., proteins and capsids. However, self-complementary assembly based on multiple host-guest systems has been scarcely reported due to the difficulty in controlling each assembly. Herein, we report a dual interaction system in which the key assembly direction is well regulated by both π-π stacking and hydrogen bonding to construct a self-complementary macrocycle. Continuous host-guest behavior of anthracene-based molecular tweezers during crystallization leads to successful construction of a cyclic hexamer, which is reminiscent of Kekulé's monkey model. Furthermore, the cyclic hexamer in a tight and triple-layered fashion shows hierarchical assembly into cuboctahedron and rhombohedral assemblies in the presence of trifluoroacetic acid. Our findings would be potentially one of metal-free strategies for constructing anthracene-based supramolecular assemblies with higher-order structure.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:19:32.905Z","creation":"2025-04-05T21:43:29.852Z"},"accession":"S-EPMC9512892","cross_references":{"pubmed":["36163173"],"doi":["10.1038/s41467-022-33357-y"]}}