{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Wang C"],"pubmed_abstract":["This study investigated the effects of trichloroisocyanuric acid (TCCA) on the bleaching and morphology of melanin-containing pathological sections. The pathological sections of 27 patients with high melanin content were bleached with 0.5% potassium permanganate, 10% hydrogen peroxide, and different concentrations of TCCA. Significant differences were found among the blank control group, 1% TCCA group (P < 0.0001). The hematoxylin-eosin (HE) score of the \"recovery pH\" HE staining group after treatment with 1% TCCA was similar to that of the \"Conventional HE\" scheme group (P > 0.05). The morphological diagnostic scores of 50 cases of pathological sections with different melanin content before and after TCCA bleaching were compared. The results showed a significant difference in the diagnost"],"journal":["Scientific reports"],"pagination":["16062"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9512931"],"repository":["biostudies-literature"],"pubmed_title":["Construction of hematoxylin-eosin, immunohistochemistry, and EBER-ISH methodology after trichloroisocyanuric acid treatment in melanin-containing tissues."],"pmcid":["PMC9512931"],"pubmed_authors":["Yang X","Sun Q","Wang C","Wang T","Wang Y","Shi J","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Construction of hematoxylin-eosin, immunohistochemistry, and EBER-ISH methodology after trichloroisocyanuric acid treatment in melanin-containing tissues.","description":"This study investigated the effects of trichloroisocyanuric acid (TCCA) on the bleaching and morphology of melanin-containing pathological sections. The pathological sections of 27 patients with high melanin content were bleached with 0.5% potassium permanganate, 10% hydrogen peroxide, and different concentrations of TCCA. Significant differences were found among the blank control group, 1% TCCA group (P < 0.0001). The hematoxylin-eosin (HE) score of the \"recovery pH\" HE staining group after treatment with 1% TCCA was similar to that of the \"Conventional HE\" scheme group (P > 0.05). The morphological diagnostic scores of 50 cases of pathological sections with different melanin content before and after TCCA bleaching were compared. The results showed a significant difference in the diagnost","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:26:39.227Z","creation":"2025-04-05T21:42:27.628Z"},"accession":"S-EPMC9512931","cross_references":{"pubmed":["36163422"],"doi":["10.1038/s41598-022-20535-7"]}}