{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vetter VM"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Deutsche Forschungsgemeinschaft (German Research Foundation)","Cure Alzheimer's Fund"],"pagination":["410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9513097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Adverse effects of psychological stress on physical and mental health, especially in older age, are well documented. How perceived stress relates to the epigenetic clock measure, DNA methylation age acceleration (DNAmAA), is less well understood and existing studies reported inconsistent results. DNAmAA was estimated from five epigenetic clocks (7-CpG, Horvath's, Hannum's, PhenoAge and GrimAge DNAmAA). Cohen's Perceived Stress Scale (PSS) was used as marker of psychological stress. We analyzed data from 1,100 Berlin Aging Study II (BASE-II) participants assessed as part of the GendAge study (mean age = 75.6 years, SD = 3.8 years, 52.1% women). In a first step, we replicated well-established associations of perceived stress with morbidity, frailty, and symptoms of depression in the BASE-II "],"journal":["Translational psychiatry"],"pubmed_title":["Epigenetic aging and perceived psychological stress in old age."],"pmcid":["PMC9513097"],"funding_grant_id":["#01UW0808; #16SV5536K, #16SV5537, #16SV5538, #16SV5837, #01GL1716A and #01GL1716B","842/7-1"],"pubmed_authors":["Kalies CH","Gerstorf D","Vetter VM","Regitz-Zagrosek V","Demuth I","Drewelies J","Sommerer Y","Bertram L"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic aging and perceived psychological stress in old age.","description":"Adverse effects of psychological stress on physical and mental health, especially in older age, are well documented. How perceived stress relates to the epigenetic clock measure, DNA methylation age acceleration (DNAmAA), is less well understood and existing studies reported inconsistent results. DNAmAA was estimated from five epigenetic clocks (7-CpG, Horvath's, Hannum's, PhenoAge and GrimAge DNAmAA). Cohen's Perceived Stress Scale (PSS) was used as marker of psychological stress. We analyzed data from 1,100 Berlin Aging Study II (BASE-II) participants assessed as part of the GendAge study (mean age = 75.6 years, SD = 3.8 years, 52.1% women). In a first step, we replicated well-established associations of perceived stress with morbidity, frailty, and symptoms of depression in the BASE-II ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:19:13.841Z","creation":"2025-04-05T21:43:37.527Z"},"accession":"S-EPMC9513097","cross_references":{"pubmed":["36163242"],"doi":["10.1038/s41398-022-02181-9"]}}