{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Howard Hughes Medical Institute","NIAID NIH HHS","National Institutes of Health","Rockefeller University"],"pagination":["e20221006"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9513381"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["219(12)"],"pubmed_abstract":["Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively. A third exposure to antigen by Delta breakthrough increases the number of memory B cells that produce antibodies with comparable potency and breadth to a third mRNA vaccine dose. A fourth antigenic exposure with Omicron BA.1 infection increased variant-specific plasma antibody and memory B cell responses. However, the fourth exposure did not increase the overall frequency of memory B cells or their general potency or breadth compared to a third mRNA vaccine dose. In"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans."],"pmcid":["PMC9513381"],"funding_grant_id":["P01 AI165075","U19 AI111825","P01 AI138938","R37-AI64003","P01-AI138398-S1","R01AI78788","UL1 TR001866","R01 AI078788","2U19AI111825","R37 AI064003","P01AI165075"],"pubmed_authors":["Canis M","Kaczynska A","Ben Tanfous T","Dizon J","Gazumyan A","Nussenzweig MC","Millard KG","Schmidt F","Cho A","Caskey M","Muecksch F","Da Silva J","Johnson B","Witte L","Wang Z","Shimeliovich I","Bednarski E","Ramos V","Zong S","Hatziioannou T","Zhou P","Raspe R","Turroja M","Oliveira TY","Bieniasz PD","Gaebler C","Jankovic M","Yao KH"],"additional_accession":[]},"is_claimable":false,"name":"Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.","description":"Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively. A third exposure to antigen by Delta breakthrough increases the number of memory B cells that produce antibodies with comparable potency and breadth to a third mRNA vaccine dose. A fourth antigenic exposure with Omicron BA.1 infection increased variant-specific plasma antibody and memory B cell responses. However, the fourth exposure did not increase the overall frequency of memory B cells or their general potency or breadth compared to a third mRNA vaccine dose. In","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T11:57:56.319Z","creation":"2024-11-12T00:22:50.359Z"},"accession":"S-EPMC9513381","cross_references":{"pubmed":["36149398"],"doi":["10.1084/jem.20221006"]}}