{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["187(4)"],"submitter":["Burman P"],"pubmed_abstract":["<h4>Objective</h4>To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).<h4>Design</h4>Electronic survey August 2020-May 2021.<h4>Results</h4>96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years ("],"journal":["European journal of endocrinology"],"pagination":["593-605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9513638"],"repository":["biostudies-literature"],"pubmed_title":["Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients."],"pmcid":["PMC9513638"],"pubmed_authors":["Mantovani G","Otto Lunde Jorgensen J","Jublanc C","Garay IB","Usui T","Mazzuco TL","Vila G","Bach L","Toth M","Schillo F","Losa M","Berinder K","Jaffrain-Rea ML","Lasolle H","Pekic S","Ekman B","Kuhn E","Korbonits M","Hubalewska-Dydejezky A","Krogh Rasmussen A","Zatelli MC","Trouillas J","Castinetti F","Syro L","Whitelaw B","Ragnarsson O","Ragonese M","Reincke M","Guenego A","Garcia C","Micko A","Christ E","Criniere L","McCormack A","Maiter D","Ritzel K","Bourcigaux N","Mallea-Gil S","Theodoropoulou M","Chanson P","Batisse-Lignier M","Bresson D","Laws ER","Hoybye C","Cortet Rudelli C","Petersenn S","Ortiz LD","Feldt-Rasmussen U","Ceccato F","ESE survey collaborators †","Larrieu-Ciron D","Dusek T","Raverot G","Popovic V","Kralievic I","Deutschbein T","Henley D","Dekkers OM","Greenman Y","Burman P","Troendle A","Chevalier N","Decoudier B","Higham C","Engstrom BE","Haissaguerre M"],"additional_accession":[]},"is_claimable":false,"name":"Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.","description":"<h4>Objective</h4>To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).<h4>Design</h4>Electronic survey August 2020-May 2021.<h4>Results</h4>96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years (","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-28T00:35:19.031Z","creation":"2025-04-07T12:26:48.047Z"},"accession":"S-EPMC9513638","cross_references":{"pubmed":["36018781"],"doi":["10.1530/EJE-22-0440"]}}