biostudies-literatureUnknown187(4)Burman P<h4>Objective</h4>To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).<h4>Design</h4>Electronic survey August 2020-May 2021.<h4>Results</h4>96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years (European journal of endocrinology593-605https://www.ebi.ac.uk/biostudies/studies/S-EPMC9513638biostudies-literatureAggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.PMC9513638Mantovani GOtto Lunde Jorgensen JJublanc CGaray IBUsui TMazzuco TLVila GBach LToth MSchillo FLosa MBerinder KJaffrain-Rea MLLasolle HPekic SEkman BKuhn EKorbonits MHubalewska-Dydejezky AKrogh Rasmussen AZatelli MCTrouillas JCastinetti FSyro LWhitelaw BRagnarsson ORagonese MReincke MGuenego AGarcia CMicko AChrist ECriniere LMcCormack AMaiter DRitzel KBourcigaux NMallea-Gil STheodoropoulou MChanson PBatisse-Lignier MBresson DLaws ERHoybye CCortet Rudelli CPetersenn SOrtiz LDFeldt-Rasmussen UCeccato FESE survey collaborators †Larrieu-Ciron DDusek TRaverot GPopovic VKralievic IDeutschbein THenley DDekkers OMGreenman YBurman PTroendle AChevalier NDecoudier BHigham CEngstrom BEHaissaguerre MfalseAggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.<h4>Objective</h4>To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).<h4>Design</h4>Electronic survey August 2020-May 2021.<h4>Results</h4>96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years (2022-01-01T00:00:00Z2022 Oct2026-05-28T00:35:19.031Z2025-04-07T12:26:48.047ZS-EPMC95136383601878110.1530/EJE-22-0440