{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilson DGS"],"funding":["British Heart Foundation","National Institute of Health Research R-01","RCUK | Biotechnology and Biological Sciences Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["1022"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9515174"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix (ECM). Severing the link between the ECM and the intracellular cytoskeleton has a devastating impact on the homeostasis of skeletal muscle cells, leading to a range of muscular dystrophies. In addition, the loss of a functional DGC leads to progressive dilated cardiomyopathy and premature death. Dystrophin functions as a molecular spring and the DGC plays a critical role in maintaining the integrity of the sarcolemma. Additionally, evidence is accumulating, linking the DGC to mechanosignalling, albeit this role is still less understood. This review article aims at providing an up-to-date perspective on the "],"journal":["Communications biology"],"pubmed_title":["The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction."],"pmcid":["PMC9515174"],"funding_grant_id":["FS/18/64/34185","PG/20/6/34835","BB/S001123/1"],"pubmed_authors":["Wilson DGS","Tinker A","Iskratsch T"],"additional_accession":[]},"is_claimable":false,"name":"The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.","description":"Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix (ECM). Severing the link between the ECM and the intracellular cytoskeleton has a devastating impact on the homeostasis of skeletal muscle cells, leading to a range of muscular dystrophies. In addition, the loss of a functional DGC leads to progressive dilated cardiomyopathy and premature death. Dystrophin functions as a molecular spring and the DGC plays a critical role in maintaining the integrity of the sarcolemma. Additionally, evidence is accumulating, linking the DGC to mechanosignalling, albeit this role is still less understood. This review article aims at providing an up-to-date perspective on the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T06:24:22.634Z","creation":"2025-04-05T21:41:15.649Z"},"accession":"S-EPMC9515174","cross_references":{"pubmed":["36168044"],"doi":["10.1038/s42003-022-03980-y"]}}