{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park BY"],"funding":["Canada First Research Excellence Fund (Fonds d'excellence en recherche Apogée Canada)","Norges Forskningsråd (Research Council of Norway)"],"pagination":["1024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9515219"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients"],"journal":["Communications biology"],"pubmed_title":["Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology."],"pmcid":["PMC9515219"],"funding_grant_id":["223273","CFREF Competition 2, 2015-2016","283798"],"pubmed_authors":["Veltman DJ","Hettwer MD","van den Heuvel OA","Franke B","Hoogman M","Valk SL","Bernhardt BC","Buitelaar J","Turner JA","Lariviere S","Schmaal L","Andreassen OA","Evans AC","Dagher A","Stein DJ","Thomopoulos SI","Paquola C","Ching CRK","Kirschner M","van Rooij D","Thompson PM","Kebets V","van Erp TGM","Park BY"],"additional_accession":[]},"is_claimable":false,"name":"Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.","description":"It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T05:19:28.763Z","creation":"2025-04-19T05:19:28.763Z"},"accession":"S-EPMC9515219","cross_references":{"pubmed":["36168040"],"doi":["10.1038/s42003-022-03963-z"]}}