biostudies-literaturePark BYCanada First Research Excellence Fund (Fonds d'excellence en recherche Apogée Canada)Norges Forskningsråd (Research Council of Norway)1024https://www.ebi.ac.uk/biostudies/studies/S-EPMC9515219biostudies-literatureUnknown5(1)It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patientsCommunications biologyMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.PMC9515219223273CFREF Competition 2, 2015-2016283798Veltman DJHettwer MDvan den Heuvel OAFranke BHoogman MValk SLBernhardt BCBuitelaar JTurner JALariviere SSchmaal LAndreassen OAEvans ACDagher AStein DJThomopoulos SIPaquola CChing CRKKirschner Mvan Rooij DThompson PMKebets Vvan Erp TGMPark BYfalseMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients2022-01-01T00:00:00Z2022 Sep2025-04-19T05:19:28.763Z2025-04-19T05:19:28.763ZS-EPMC95152193616804010.1038/s42003-022-03963-z