{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112"],"submitter":["Ma Y"],"pubmed_abstract":["<h4>Background</h4>Coronavirus disease 2019 (COVID-19) continues to be a major global public health challenge, with the emergence of variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current vaccines or monoclonal antibodies may not well be protect against infection with new SARS-CoV-2 variants. Unlike antibody-based treatment, T cell-based therapies such as TCR-T cells can target epitopes that are highly conserved across different SARS-CoV-2 variants. Reportedly, T cell-based immunity alone can restrict SARS-CoV-2 replication.<h4>Methods</h4>In this study, we identified two TCRs targeting the RNA-dependent RNA polymerase (RdRp) protein in CD8 + T cells. Functional evaluation by transducing these TCRs into CD8 + or CD4 + T cells confirmed their specificity.<h4>Resul"],"journal":["International immunopharmacology"],"pagination":["109283"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9515335"],"repository":["biostudies-literature"],"pubmed_title":["Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19."],"pmcid":["PMC9515335"],"pubmed_authors":["Wang M","Tian G","Qiao D","Ma Y","Deng L","Li B","Zhou H","Nielsen M","Liu F","Peng K","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19.","description":"<h4>Background</h4>Coronavirus disease 2019 (COVID-19) continues to be a major global public health challenge, with the emergence of variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current vaccines or monoclonal antibodies may not well be protect against infection with new SARS-CoV-2 variants. Unlike antibody-based treatment, T cell-based therapies such as TCR-T cells can target epitopes that are highly conserved across different SARS-CoV-2 variants. Reportedly, T cell-based immunity alone can restrict SARS-CoV-2 replication.<h4>Methods</h4>In this study, we identified two TCRs targeting the RNA-dependent RNA polymerase (RdRp) protein in CD8 + T cells. Functional evaluation by transducing these TCRs into CD8 + or CD4 + T cells confirmed their specificity.<h4>Resul","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-05-31T22:40:42.764Z","creation":"2024-11-10T03:46:27.876Z"},"accession":"S-EPMC9515335","cross_references":{"pubmed":["36201943"],"doi":["10.1016/j.intimp.2022.109283"]}}