biostudies-literatureUnknown9Qiao Z<h4>Background</h4><i>Sparassis latifolia</i> (<i>S. latifolia</i>) is a precious edible fungus with multiple biological activities. To date, no study has been investigated the underlying molecular mechanism of immunoregulation caused by the neutral polysaccharide of <i>S. latifolia.</i><h4>Materials and methods</h4>To investigate immunomodulatory mechanism of <i>S. latifolia</i> neutral polysaccharide (SLNP), SLNP was obtained from <i>S. latifolia</i> and its structure, immune receptors and regulation mechanism were studied.<h4>Results</h4><i>S. latifolia</i> neutral polysaccharide consisted of arabinose, galactose, glucose, xylose, and mannose with a molar ratio of 6:12:63:10:5. SLNP was a pyran polysaccharide with a relative molecular weight of 3.2 × 10⁵ Da. SLNP promoted theFrontiers in nutrition994971https://www.ebi.ac.uk/biostudies/studies/S-EPMC9515474biostudies-literatureEffects of <i>Sparassis latifolia</i> neutral polysaccharide on immune activity <i>via</i> TLR4-mediated MyD88-dependent and independent signaling pathways in RAW264.7 macrophages.PMC9515474Wang MChang MCheng FCao JYun SQiao ZFeng CZhao YCheng YfalseEffects of <i>Sparassis latifolia</i> neutral polysaccharide on immune activity <i>via</i> TLR4-mediated MyD88-dependent and independent signaling pathways in RAW264.7 macrophages.<h4>Background</h4><i>Sparassis latifolia</i> (<i>S. latifolia</i>) is a precious edible fungus with multiple biological activities. To date, no study has been investigated the underlying molecular mechanism of immunoregulation caused by the neutral polysaccharide of <i>S. latifolia.</i><h4>Materials and methods</h4>To investigate immunomodulatory mechanism of <i>S. latifolia</i> neutral polysaccharide (SLNP), SLNP was obtained from <i>S. latifolia</i> and its structure, immune receptors and regulation mechanism were studied.<h4>Results</h4><i>S. latifolia</i> neutral polysaccharide consisted of arabinose, galactose, glucose, xylose, and mannose with a molar ratio of 6:12:63:10:5. SLNP was a pyran polysaccharide with a relative molecular weight of 3.2 × 10⁵ Da. SLNP promoted the2022-01-01T00:00:00Z20222025-05-18T13:39:57.045Z2024-10-18T22:47:56.407ZS-EPMC95154743618569110.3389/fnut.2022.994971