{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(15)"],"submitter":["Wang Y"],"pubmed_abstract":["<b>Rationale:</b> Hyperactivation of Hippo-Yes-associated protein (YAP) signaling pathway governs tumorigenesis of gastric cancer (GC). Here we reveal that minichromosome maintenance complex component 6 (MCM6) is a critical transcriptional target of YAP in GC. We aim to investigate the function, mechanism of action, and clinical implication of MCM6 in GC. <b>Methods:</b> The downstream targets of YAP were screened by RNA sequencing (RNA-seq) and microarray, and further validated by chromatin immunoprecipitation PCR and luciferase reporter assays. The clinical implication of MCM6 was assessed in multiple GC cohorts. Biological function of MCM6 was evaluated <i>in vitro</i>, in patient-derived organoids, and <i>in vivo</i>. RNA-seq was performed to unravel downstream signaling of MCM6. Poten"],"journal":["Theranostics"],"pagination":["6509-6526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9516235"],"repository":["biostudies-literature"],"pubmed_title":["MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target."],"pmcid":["PMC9516235"],"pubmed_authors":["Wu WKK","Kang W","Zhang J","Ma BBY","Lo KW","Wong CC","Chen H","Yu J","Chen B","Liu W","Zhou Z","To KF","Zhang Y","Cheung AHK","Liang L","Chan MWY","Cheng ASL","Wang Y","Yan H"],"additional_accession":[]},"is_claimable":false,"name":"MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.","description":"<b>Rationale:</b> Hyperactivation of Hippo-Yes-associated protein (YAP) signaling pathway governs tumorigenesis of gastric cancer (GC). Here we reveal that minichromosome maintenance complex component 6 (MCM6) is a critical transcriptional target of YAP in GC. We aim to investigate the function, mechanism of action, and clinical implication of MCM6 in GC. <b>Methods:</b> The downstream targets of YAP were screened by RNA sequencing (RNA-seq) and microarray, and further validated by chromatin immunoprecipitation PCR and luciferase reporter assays. The clinical implication of MCM6 was assessed in multiple GC cohorts. Biological function of MCM6 was evaluated <i>in vitro</i>, in patient-derived organoids, and <i>in vivo</i>. RNA-seq was performed to unravel downstream signaling of MCM6. Poten","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T15:56:46.352Z","creation":"2025-04-04T12:45:29.307Z"},"accession":"S-EPMC9516235","cross_references":{"pubmed":["36185598"],"doi":["10.7150/thno.75431"]}}