biostudies-literatureSousa TDCConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMinistério da Saúde944277https://www.ebi.ac.uk/biostudies/studies/S-EPMC9516282biostudies-literatureUnknown10The influenza A virus (IAV) is of a major public health concern as it causes annual epidemics and has the potential to cause pandemics. At present, the neuraminidase inhibitors (NAIs) are the most widely used anti-influenza drugs, but, more recently, the drug baloxavir marboxil (BXM), a polymerase inhibitor, has also been licensed in some countries. Mutations in the viral genes that encode the antiviral targets can lead to treatment resistance. Worldwide, a low prevalence of antiviral resistant strains has been reported. Despite that, this situation can change rapidly, and resistant strain surveillance is a priority. Thus, the aim of this was to evaluate Brazilian IAVs antiviral resistance from 2017 to 2019 through the identification of viral mutations associated with reduced inhibition ofFrontiers in public healthLow prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasons.PMC9516282401851/2015-0Rodrigues RRMotta FMartins JSCCde Almeida WAFGarcia CCSiqueira MMBrown DResende PCDebur MDCSantos KCOCavalcanti ACGregianini TSFerreira JASantos CAFernandes SBSousa TDCPereira FMMiranda MDMatos ADRIani FCMfalseLow prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasons.The influenza A virus (IAV) is of a major public health concern as it causes annual epidemics and has the potential to cause pandemics. At present, the neuraminidase inhibitors (NAIs) are the most widely used anti-influenza drugs, but, more recently, the drug baloxavir marboxil (BXM), a polymerase inhibitor, has also been licensed in some countries. Mutations in the viral genes that encode the antiviral targets can lead to treatment resistance. Worldwide, a low prevalence of antiviral resistant strains has been reported. Despite that, this situation can change rapidly, and resistant strain surveillance is a priority. Thus, the aim of this was to evaluate Brazilian IAVs antiviral resistance from 2017 to 2019 through the identification of viral mutations associated with reduced inhibition of2022-01-01T00:00:00Z20222026-04-08T11:46:33.005Z2024-12-03T20:25:25.215ZS-EPMC95162823618769110.3389/fpubh.2022.944277