{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi DD"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["e62-e74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9516432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute to tumour proliferation, stress adaptation, immunomodulation, metastasis, electrical hyperactivity and seizures, and neuropathic pain. Collectively, this expanding knowledge base reveals multiple therapeutic avenues for cancer neuroscience that warrant further exploration in clinical studies. We discuss the available clinical data, including ongoing trials investigating novel agents targeting the tumour-nerve axis, and the therapeutic potential for repurposing existing neuroactive drugs as an ant"],"journal":["The Lancet. Oncology"],"pubmed_title":["Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities."],"pmcid":["PMC9516432"],"funding_grant_id":["P01 CA247886","T32 GM007753","R01 CA197296","P50 CA062924"],"pubmed_authors":["Shi DD","Mino-Kenudson M","Schenkel JM","Su J","Wo JY","Loeffler JS","Wang TC","Jacks T","Shih HA","Hong TS","Zheng L","Hwang WL","Guo JA","Aguirre AJ","Wen PY","Hoffman HI","Barth JL"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities.","description":"With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute to tumour proliferation, stress adaptation, immunomodulation, metastasis, electrical hyperactivity and seizures, and neuropathic pain. Collectively, this expanding knowledge base reveals multiple therapeutic avenues for cancer neuroscience that warrant further exploration in clinical studies. We discuss the available clinical data, including ongoing trials investigating novel agents targeting the tumour-nerve axis, and the therapeutic potential for repurposing existing neuroactive drugs as an ant","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-10T06:51:21.789Z","creation":"2025-02-19T03:25:54.917Z"},"accession":"S-EPMC9516432","cross_references":{"pubmed":["35114133"],"doi":["10.1016/S1470-2045(21)00596-9","10.1016/s1470-2045(21)00596-9"]}}