{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Kaku CI"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pubmed_abstract":["Understanding the evolution of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of next-generation vaccines. Here, we tracked SARS-CoV-2 receptor binding domain (RBD)-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in mRNA-vaccinated individuals. Cross-reactive serum neutralizing antibody and memory B cell (MBC) responses declined by two- to four-fold through the study period. Breakthrough infection elicited minimal de novo Omicron-specific B cell responses but drove affinity maturation of pre-existing cross-reactive MBCs toward BA.1. Public clones dominated the neutralizing antibody response at both early and late time points, and their escape mutation profiles predicted newly emergent Omicron "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2022.09.21.508922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9516849"],"repository":["biostudies-literature"],"pubmed_title":["Evolution of antibody immunity following Omicron BA.1 breakthrough infection."],"pmcid":["PMC9516849"],"funding_grant_id":["P30 CA023108","UM1 AI144462","K99 AI166250","R01 AI141707"],"pubmed_authors":["Geoghegan JC","Zhou P","Walker LM","Song G","Starr TN","Burton DR","Bloom JD","Raiees A","Kaku CI","Dugan HL","Khalife P","Champney ER","Mielcarz DW"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of antibody immunity following Omicron BA.1 breakthrough infection.","description":"Understanding the evolution of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of next-generation vaccines. Here, we tracked SARS-CoV-2 receptor binding domain (RBD)-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in mRNA-vaccinated individuals. Cross-reactive serum neutralizing antibody and memory B cell (MBC) responses declined by two- to four-fold through the study period. Breakthrough infection elicited minimal de novo Omicron-specific B cell responses but drove affinity maturation of pre-existing cross-reactive MBCs toward BA.1. Public clones dominated the neutralizing antibody response at both early and late time points, and their escape mutation profiles predicted newly emergent Omicron ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-05T03:15:40.3Z","creation":"2025-04-03T21:30:40.366Z"},"accession":"S-EPMC9516849","cross_references":{"pubmed":["36172124"],"doi":["10.1101/2022.09.21.508922"]}}