{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patti MA"],"funding":["Chemicals Management Plan at Health Canada, the Ontario Ministry of the Environment, and the Canadian Institutes for Health Research","NIEHS NIH HHS"],"pagination":["11332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9517145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(18)"],"pubmed_abstract":["Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associatio"],"journal":["International journal of environmental research and public health"],"pubmed_title":["Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes."],"pmcid":["PMC9517145"],"funding_grant_id":["R01 ES025214","R01 ES032386","R01 ES024381","MOP-81285"],"pubmed_authors":["Papandonatos GD","Patti MA","MacFarlane AJ","Braun JM","Fisher M","Ashley-Martin J","Lanphear BP","Muckle G","Fraser WD","Kelsey KT","Arbuckle TE"],"additional_accession":[]},"is_claimable":false,"name":"Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.","description":"Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associatio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T05:16:36.034Z","creation":"2025-04-19T05:16:36.034Z"},"accession":"S-EPMC9517145","cross_references":{"pubmed":["36141604"],"doi":["10.3390/ijerph191811332"]}}